I have been on them ALL!! Most recent is Pristiq...50mg....for 1 year. Seems to have stopped working and I am flat line and no motivation! Dr just switched me to Cymbalta 30mg....would love to hear how it worked for you! Weight gain??? I don't usually gain anything more than 5 pounds but on my small build that is a clothing size...Does this one tend to stop working after time? How is it for your depression and anxiety?? I have NO Anxiety on Pristiq but started getting break thru....I would appreciate your experiences!