here is my experience with Actos (and other meds too):
I became diabetic roughly oct 1998, spent first 1.5 years on glucophage and first glyburide then glipizide neither one helped much at all so at the 2 year mark from diagnosis I had to start insulin injections. Doc took me off the glipizide stayed on glucphage and started humulin insulin about 35 units twice a day. some improvement but not anywhere near controlled enough.
In Oct 2001 I started the Actos and had some fatigue achiness for about 6 weeks, I have always had appetite loss because I also get migraines and have Meniere's disease so I don't know if that affected me at all in that area.. but for me at least, I DID acclimate to the actos with no other ill effects and within 2 months of taking it I had WONDERFULLY controlled levels, my fasting levels dropped from 200-250 to 100-120s, and my glycolated hemoglobins (the 3 month test) was immed improved going from 8.1 in dec 2001 to 6.0 in mar 2002, and as low as 4.9 in May 2002. so obviously the actos needs a little time to show the improvement and you can decided whether the side effects are worth it for you or to discuss other options with your doctor.
For what it is worth, I just had the workups in dec 2002 and had 6.1 glycolated hemoglobin, and my cholesterol (as high as 800 at one point before starting lipitor and prinivil) was 183 for total cholesterol, only 88 LDL and 49 HDL. THOSE are results I can LIVE with
my injection amounts have also been lowered to 38 units in AM and only 15 in PM. For me Actos was worth the trouble, only you can decide what will work/be worth the effects for you. I despise the glucophage, after all these years I still have not gotten used to the awful stomach cramps and diarhea but when I sneak off it for even 2 weeks my numbers creep back up so I will stay on it and suffer the side effect knowing it will add years to my life with my loving husband.
hope my history and info can help you...