Re: Does anyone know why metformin does not work as well as Glipizide for me?
Glipizide is a sulfonylurea drug, and they work by forcing the pancreas to produce more insulin, rather than by decreasing the insulin resistance. Unfortunately, the use of sulfonylureas can actually accelerate the wearing out of the insulin-producing cells, and can cause one to need insulin sooner, rather than later. If decent results (and an A1c of 6.7 is still pretty decent) can be achieved without sulfonylureas, then that is definitely a better way to go.
You mentioned that you had increased the metformin for only a month, and you mentioned that you didn't see much improvement in your daily numbers. First of all, your individual blood stick tests only capture a few moments in the day...they don't capture what your bg was doing 24/7. It would be much better to try the increased metformin for at least 3 months, and have an A1c at the end of that time to determine if, in fact, it was actually helping. If not, then glipizide might be needed, but only if your A1c keeps creeping up, and especially if you start getting closer to 7.0.
Last edited by SamQKitty; 11-20-2010 at 11:44 AM.