Re: Grape Fruit
I undestand that any drug which works via the P450 liver pathway, is risky to take with Grapefruit. Many Calcium Blockers (Norvasc) and Statins are broken down by this pathway. The statin Pravachol and Lescol do not work via this enzyme, and do not (supposedly) have this effect with grapefruit. I take Pravachol and also drink Grapefruit juice several days a week without any problems. The same holds true for many drugs which are taken together. Negative drug interractions happen very often due to the P450 enzyme. A doctor should be knowledgeable of drugs which cannot be taken together. Unfortunately, the major cause of death in this country is medication errors. Dr. Sinatra, wrote an article recently on the Grapefruit controversy. He mentioned Zocor, Mevacor and Lipitor as the most dangerous statins to take with grapefruit. He also mentioned the dangers of grapefruits effect on Estrogen levels for women.