The reason I asked is because I just discovered that Xanax, which I have been taken to help me through this ordeal, actually reduces the tone of a the LES. Catch 22, eh? Same thing with certain anti-depressants, apparently. Also, I took Ditropan XL for urinary problems for close to 6 months - it is an anticholinergic which I know reduces LES tone. I suspect it had something to do with my problems. Anyway, I'll keep looking for more. Later.