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Old 07-09-2008, 02:38 PM   #1
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High ALT liver enzymes. What are common causes?

What are common causes of high ALT scores?

My liver/abdominal ultrasound was normal. Could intestinal problems cause elevated ALT?

I'm long overdue for a colonoscopy, and I have a lot of lower abdominal pain.

I'm scheduled for a HIDA scan, even though I don't have a lot of gall bladder symptoms. I'm just starting to read about it, so maybe I'm wrong.

Non-alcoholic fatty liver seems to make more sense.

 
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Old 07-09-2008, 08:17 PM   #2
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Re: High ALT liver enzymes. What are common causes?

There are many causes - but I will tell you a short story of mine. Since 1995, I have fought this. (First - avoid the antibiotic ofloxin). This can be casued by gall bladder issues, and SOD Sphinker of Oddi. It took 13 years of "attacks" and ending up in the hospital, before I found a GREAT Dr who finally diagnosed me with SOD. I am a woman in the "old south" so I was told for years that I was just a weak helpless woman and it was all in my mind. Please, find someone who can help. They may want to do an ERCP. I have had two in the last four months. If you are on the east coast, I can recommend a hospital and Dr, Good luck. Stay away from all alcohol, fatty food, and try accupuncture for pain if necessary.

 
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Old 07-09-2008, 08:18 PM   #3
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Re: High ALT liver enzymes. What are common causes?

I finally had my gall bladder out this last spring---
I had high liver enzyme levels for years---but things were compounded by
"fatty liver" due to undiagnosed and undermedicated thyroid disorder---and other endocrine problems.
At the ER, they asked me about hepatitis---NOPE.
About taking too much of an unspecified vitamin---NOPE.
Then they poked me in the right side---and I cringed----YUP, sounds like gallbladder.

Another thing to consider is checking out Cushings---a lot of folks who have this, also have "fatty liver" and high liver enzymes---and the problem is hypercortisolima due to pituitary tumor, adrenal disease or cortisol secreting tumor in lungs or other part of the body.

 
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Old 07-10-2008, 11:55 PM   #4
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Re: High ALT liver enzymes. What are common causes?

lucylucy,
As you know a Liver Function Test is a blood test used to test your liver. But it really does not test your liver function.

ALT is a liver enzyme that is only contained in the liver and along with AST another liver enzyme that is in other organs-- the liver use these enzymes to metabolize amino acids and make proteins. When they die, they leak into the blood stream.

About 5% of people have a high level of ALT in their blood. If your level is higher than 100 U/L you should have additional testing to find what is causing this elevation--- many things can elevate this enzyme---from a fatty liver to Hepatitis. But, it is not elevated by intestinal problems but a damaged or inflammed liver.

I wish you well---Harry

Last edited by Harry; 07-11-2008 at 12:13 AM. Reason: typos

 
Old 07-11-2008, 12:54 AM   #5
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Re: High ALT liver enzymes. What are common causes?



I have gallbladder problem without stones, but low liver enzyme:

AST = 10 normal range should be 10~40
ALT = 11 normal being 9~60

I had them around the 20's previously. Doesn't make sense that they went low months after I discover this low-functioning gallbladder...

 
Old 07-12-2008, 01:08 PM   #6
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Re: High ALT liver enzymes. What are common causes?

Okay, I just found this site and would like to know if anyone has any advice for me. I am a 38 year old mother of 3, I developed pancreatitis when I was 19 and pregnant with my first son, have had problems 1 or 2 times a year, until 2 years ago when I developed pain pretty regularly, sick 2 weeks, okay for about 10 days then start all over again. I went to a GI pancreatitis specialist in dec of last year, had genetic testing done, plus amalayse and lipase, both high and liver function which were normal. The genetic testing came back positive for spinkt1, mom also has pancreatitis, and a cousin died from pancreatic cancer at 34. So then we did a EUS and a MRCP. Both came back okay, thought maybe there was sludge in the gall bladder. So on 6-18-2008 I had my gallbladder removed via lap. Results showed a perfectly fine gb. Well I woke up from surgery have a pancreas attack, which lasted about 10 days. Then came back and hasn't left. Had labs done on 6-30, the amalyse was okay lipase was 400, about 3 days after last affects of attack, but now the liver functions were sky high around 900, I am scheduled for an ERCP the end of July, but not sure if I can make it. Had more lab done on thursday, haven't heard if it is worse. The GI said I have SOD type I. The question I have is, what is this doing to my liver and pancreas, it cannot be good to have them high for this long, my lipase hasn't been under 400 in 2 years, and now my liver, plus the contant pain and throwing up, I have lost 7 lbs. since surgery, and so know I am 5'7 123lbs. uggg sorry this is so long, I am really tired of this. Thanks for listening, any responce would be great.

 
Old 07-12-2008, 04:05 PM   #7
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Re: High ALT liver enzymes. What are common causes?

I've found a lot of stuff regarding Spink 1 and Septo-Optic Dysplasia Type 1 by doing a search on the internet.
There's a whole lot of stuff to look at---these things seem to manifest themselves in different ways.
I hope you do a search and learn more about them---and I'd check a "rare diseases" and "clinical trials" websites.
Good luck with everything.

Last edited by moderator2; 07-12-2008 at 05:31 PM. Reason: unnecessary to quote the previous post

 
Old 07-12-2008, 05:06 PM   #8
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Re: High ALT liver enzymes. What are common causes?

Thanks for the reply t4t3hell, I guess I didn't explain very well, by SOD I meant sphincter of oddi disfuction, which has a lot of the same pain and labs as pancreatitis.
Thanks

 
Old 07-12-2008, 08:03 PM   #9
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Re: High ALT liver enzymes. What are common causes?

Oh...gotcha!!!
The other Sod!!!

 
Old 10-22-2009, 08:09 AM   #10
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Re: High ALT liver enzymes. What are common causes?

My ALT Liver enzyme was 76 and the normal level should be between (U/L) 12-48. My doctor explained it could be fatty liver or hepititis. She is going to wait another 4 months to retake the test. She wants me to lose 50 lbs. I already lost 60 lbs. That is all I have left to lose is 50lbs. Anyway, I had my gallbladder removed a year ago. I do have bile issues which I take a bile binder and I have cholesterol problems but I got it down for 187. I have high blood pressure but managed. I exercise and eat right. I also go to acupuncture. Over the summer months I went to a gasterologist to test for digestive problems because I haven't been the same since my gall bladder has been removed. I also went and had a colonoscopy about a month ago because I thought I developed IBS. I am 41 years old. I do have digestive issues but I know it is a bile problem. My liver enzymes have gone up before and then went down.


My question is this kinda of scares me - Has this happened to anyone before? I am hoping all it is but fatty liver. Could stress do this to you? I feel pain in my right upper rib where my gall bladder used to be but I was told it might be SOD. I was taking antibiotics when she took the blood test for my liver and I heard antibiotics can do this. I had a UTI at the time. I already had a pancritis test which was normal. I had my thyroids checked - normal. I had a complete physical and a mamogram. I had an extensive xray done of where my gallbladder used to be and they found no extra stones left behind because I had so many digestive problems when my gall bladder was removed. I mean my body was checked from head to toe. I don't think I had a hepititus test yet.

 
Old 12-02-2009, 12:57 PM   #11
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Re: High ALT liver enzymes. What are common causes?

I'm new to this board. I recently had a physical done with blood tests. My physician called me back and told me that I had elevated liver function enzymes. My ALT was normal but my AST was 90.
I don't drink or smoke, but I do take high levels of protein (via nutritional shakes) and Creatine (which has some "partially hydrololyzed polyvinyl alcohol" and "ethyl alcohol").
I went to take a US which my doctor said showed that I have a 2cm cyst, however she didn't see any damage to the liver. I'm going to take a CT scan tomorrow.

Could the Creatine and/or added protein contribute to the high liver function results?

 
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