I've been on a slightly higher dosage of zonegram (400mg) for about 3months (reduced to 300mg due to the side effects). I've had more extreme reactions (primarily mood related, loss of appetite, excessive thirst, sour taste in mouth). I'm 36, 195lbs, and about to be married (I say that b/c the pressures combined w/the medicine makes me more nervouse the closer I get to our wedding), and the mood/anxiety reactions are unlike anything I've experienced before. Uncomfortable. Slowly getting better. I don't want to scare you away, because if the drug works, the results I'm sure outweigh the side effects. good luck.