I have had 2 post surgical infections.
The first was osteomyelitis during an ankle fusion with an external fixator2 years ago. I went to the emergency room 3 times in excruciating pain before they figured out that it was infected. I had to have 2 debridements and was hospitalized for 3 weeks. I had a picc line and did the antibiotics for 8 weeks. The whole experience was awful.
The second was last year following a bunionectomy (Keller Procedure with 2 pins in my right great toe). This time it was just cellulitis (to begin with). Thank God they took me seriously when I called my ortho. He hospitalized me immediately for a few days. I had a new picc line and did the antibiotics for 4 weeks. They assumed the infection hadn't reached the bone because the site where the pins entered my toe did not appear to be infected. However, approx 2 weeks after going off the antibiotics, the infection was back and the bone pain was awful!!! They finally did an MRI and found the infection was in the bone. I went back on the antibiotics for another 4 weeks. So far, I have had no recurrence of infection. I think I am in the clear.
I am not sure what boot you are wearing, but I have found that the super thick athletic socks work well protecting the skin of my foot and ankle. Also, one of my drs gave me some padding I could use if the boot was uncomfortable. Finally, I have also used an air cast and it was the most comfortable thing I have ever used! Maybe you could ask your dr for some suggestions, although the nurses are the ones who usually know all the tricks.
I am glad you are here on this board. I have found it an excellent place to learn, "sound off," and find encouragement when I need it.
Good luck and keep posting!