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Old 04-04-2006, 11:31 AM   #1
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Ibuprofen use - GERD? Liver? Gall bladder?

Hi, I知 new here! In fact, I知 new to MAJOR digestive disorders (not that I don稚 know all about gas, IBS, flu, hunger, or other every-day things)! Unlike some apparently (waiting for years? No way! ), I was alarmed when I seemed to change suddenly as far as my stomach reactions, etc, and wasted no time going to doctors!

I知 awaiting a bunch of test results now (blood, fecal [yes, my stools have seemed to be greenish for a while sorry to TMI ], endo, sonogram), and anxiously awaiting my 吐ollow-up which isn稚 for a month! (I suppose doc himself would hurry it up if they were really alarmed, but.)

Bottom line, I believe my massive ibuprofen use has led to something. Either that, or perhaps it was just an aggravating factor that痴 really a blessing, in that maybe it痴 pointed out something that痴 already wrong. I致e heard sometimes people really aren稚 aware things are poor with them.

Last July I started taking 3x/day 800 mg ibu for an excruciating rear-end problem that suddenly turned up for no obvious reason. It was so bad I guess I continued the 3x for up to 3 mos (maybe just 2), then the next refill for a few mos I took just 2x/day, then from Nov on I took just 1x/day in the morning w/o any food (I generally don稚 eat breakfast) until I stopped (essentially, the whole entire prescription but I stopped 2 pills from the end because it got so bad and I was scared).

I had some strange symptoms in Jan just before I stopped the ibu. Included strangely feeling sickly after eating BBQ meal, I even noted to a co-worker 澱oy I致e been hiccupping a lot lately, and then WHAM, constant, incessant 澱urping (not sure, I never really burp I call it a throat-burp where there痴 fibrillation from the stomach up thru my throat) for 2 days straight, and that nasty feeling you get if you池e ever sensitive to aspirin/ibu type of pills. I.e., it 鍍asted just like the ibu all over in my gut and esophagus. Then my husband got real sick and I too had it in dribs and drabs which seemed to erase all those other symptoms. Then as I got all 澱etter, some of the burping came back and that general yucky feeling again. I went to my regular doc who said I probably had GERD and said I could do a trial on Nexium, but would probably have to go thru a bunch of tests. I took the Nexium (still on it, 1x/day), hoping to avoid tests. But while most of the gastric problems seemed to subside, the main problem became my throat scratchiness, too much phlegm, sore, warm to burning feeling, 菟hlegm in my mouth痴 rear especially after sleep, etc. All the while I知 reading stuff about GERD and pretty terrified. In fact, I知 sure I probably have LPRD specifically at least as far as symptoms! I ended up calling my mom痴 GI doc and luckily got a timely appt.

He set me up for several aforementioned tests also very timely. At the end of the endo last week, he said I have hiatal hernia and maybe too much bile, but told me to continue on 1x/day Nexium for now.

I知 dying to get to the bottom of this. While I told the GI that I highly suspect the ibuprofen has somehow done me wrong, I don稚 hear much yet from him about that. (The only real acknowledgement of it was when he told me I was bad for taking it without breakfast/food.)

Does anyone have any idea how ibu (NSAIDs) may lead to either LIVER/GALL problems, and/or GERD?

I don稚 know where the hernia may have come from (maybe the abdominal exercises I have been doing since Nov from physical therapy for my rear-end?), but I知 still concerned about BILE. I cannot believe the NSAIDs had nothing to do with this whole horrible thing. Yet I haven稚 seen much in all my too-much reading about NSAIDs and liver function or gall function, etc. (I have in the last few days gone to actually feeling rather sickly in my stomach, not just throat problems.)

Another related question is what would cause EXCESS bile? I still haven稚 figured that out. I seem to see things about the gallstones, liver failure, etc, allowing too LITTLE bile.

I know I need to talk to my doc more, but I知 just dying! (Or that痴 what I知 afraid I知 doing!) Does anyone have any experience with NSAID use beating up the GI system? Besides ulcers (said nothing about that)?

Sorry this is sort of rambling there痴 so much to say! But if you can help me out with facts or even some opinions, I壇 appreciate it!

 
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Old 04-04-2006, 02:05 PM   #2
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Re: Ibuprofen use - GERD? Liver? Gall bladder?

Have you been able to stop taking Ibuprofen? If so hopefully whatever damage the Ibuprofen caused will heal.

In regards to LPR, if you really have LPR you will probably need a greater dose of nexium or another PPI.

Hopefully you wont need Nexium, and hopefully just by stopping ibuprofen or by taking ibuprofen with food your symptoms will resolve.

 
Old 04-04-2006, 05:45 PM   #3
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Re: Ibuprofen use - GERD? Liver? Gall bladder?

Thank you for checking in!

No, I stopped ibuprofen end of Jan. I should have stopped taking it in Dec when therapy seemed to be definitely helping - but I was too scared to stop! (You wouldn't believe the pain!)

That was when the symptoms really, really started. I may have some improvement thanks to the Nexium (can't really tell, didn't allow condition to continue without seeing doctor soon), but I'm not sure. I still get many throat conditions, and many burps; this past weekend I actually felt more nauseous for the 1st time; finally think I'm getting over it.

I know about the 2x/Nexium recommendation for LPRD, and have mentioned it to the GI both at the initial consult and after the endo. But he just told me to keep with 1x/day. I'll probably be pushing that idea again when I see him!

 
Old 04-04-2006, 07:14 PM   #4
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Re: Ibuprofen use - GERD? Liver? Gall bladder?

I unfortunately have a similar experience as you. I had been taking antiinflammatory meds for 13 years (chronic pain) no problem, then bam one day I started having some of the symptoms you describe. I had to stop my prescription and now I'm in more severe chronic pain with no relief. Scared, I was terrified to stop since I can't hardly function without the meds. Since those types of meds are pain killers I was unaware that my stomach was in pain until I got so bad that I knew something was wrong. I always followed the directions on the pills to take with food, don't lie down until 30 minutes, never drank coffee or alcohol or spicy foods but still it has hit me like a lead balloon. I have yet to be seen by a specialist, still waiting but I'm taking Aciphex 2x/day and am able to eat although feel sick to my stomach sometimes. I was also burping and thought that carbonated water or ginger ale would help but that made it worse I know now. I hope niether of us have permanent damage. Dealing with so much pain is a drag.

 
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