In my opinion you should pay more attention to joint cartilage as cartilage provides a slick buffer so that bone ends can easily glide over each other during movement.
Especially for those who lead an active lifestyle, the cumulative effects of wear and tear can trigger the breakdown of joint cartilage. The more it is worn away, the more bones rub together creating pain, stiffness, inflammation, swelling and joint deformities. Glucosamine may helps to ease your problem with your knees and ankles and reduce pains.
What is Glucosamine?...
Glucosamine -- a substance naturally available throughout the body, but chiefly found in the cartilage contributes to the health and strength of your joints. It helps to maintain healthy cartilage to help ensure healthy joints and unrestricted, pain-free movement.
Do not take drugs such as aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) as they come along with long term side effects although they may be effective to combat the problem.
Hope my advise may help you solve your problems. Have a nice day