Re: Could Prednisone cause this?
Anxiety can cause widespread muscle aches, and simple things like low B12, vitamin D or calcium can cause muscle spasms.
But some people are very sensitive to even low doses of prednisone, which can have many, many different side effects. The muscle tightening/burning sensation could be a serious side effect - especially since this has happened twice - call your doctor. I hope you feel better, side effects or not!