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Old 10-25-2007, 08:14 AM   #1
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Isosorbide mononitrate question

My GP has told me to take 10mg of isosorbide mononitrate twice daily, but with no times. Looking at the Electronic Medicines Compendium, it says they should be taken to allow a nitrate-free interval (presumably overnight.) Does this mean they should be at about 7am and 5pm rather than more evenly-spaced? How do others handle it.

I have had a headache today - also a bit of chest pain.
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Old 10-25-2007, 12:52 PM   #2
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Re: Isosorbide mononitrate question

Quote:
Originally Posted by asc01 View Post
My GP has told me to take 10mg of isosorbide mononitrate twice daily, but with no times. Looking at the Electronic Medicines Compendium, it says they should be taken to allow a nitrate-free interval (presumably overnight.) Does this mean they should be at about 7am and 5pm rather than more evenly-spaced? How do others handle it.

I have had a headache today - also a bit of chest pain.
Hi asc01, isosorbide is a slow acting nitro for angina, and it is recommended to discontinue for an interval to avoid developing a resistance/tolerance for the treatment.

I had been on the drug for more than 3 years (10mg 2X daily) for stable angina. For several months now I will take isosorbide (10mg)just before going for exercise on the treadmil, and sometimes I skip the isosorbide for the fast acting nitro pill and take it if and when angina develops while exercising.

Do you have unstable angina (chest pain without exercise or stress)? My routine was about the same time interval as you have and no problems. Do you need to be continously medicated on a nitrate? I thought it was necessary for me, but experiencing angina at specific times, I will take as needed!... Nitrate will cause a headache...however, that was not my experience.

 
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