Yes, I have had very bad experiences with beta blockers. I was changed to Bystolic just a few days ago (a different kind of bb) and the difference is dramatic. If you want to read my last few posts on the lupus board, I go into boring detail. My appetite has improved and my indigestion is so much better. However, I do have problems with IBS and GERD, so I know my stomach problems will not be gone forever. As with most medications, unless it is contraindicated, I try to take them with a meal. Hope this helps.