It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....



Hepatitis Message Board
Post New Thread   Closed Thread
LinkBack Thread Tools
Old 02-01-2004, 09:57 AM   #1
Junior Member
 
Join Date: Aug 2003
Location: Highland,N.Y. U. S.A.
Posts: 25
Unzzz2003 HB User
Higher Enzymes Post Trtment.

Hello All; I haven't been here for a while, just got some bloodtest results and wanted to jump in here. I did trtment and stopped responding after 10 months so stopped trtment about 15 months ago. My recent bloodwork now shows my ALT&AST higher than ever before. I used to run in the 80's or so for both, now my ALT is 158 and AST 105 and Viral load which I don't worry about much is back up 16 Million. Just wondering if anyone has gone thru the same thing. I am wondering just how great things truly are after trtment for non-responders, and if things get worse. Thanbey, I think We had started to talk about this when I disappeared for a while. Any input? 2 and a half years ago on biopsy I was Stage 3 Fibrosis as well as Stage 3 inflamation
with moderate piecemeal necrosis and mod. portal infiltrates. Hope All Are doing WELL. Thanks.....Peace.......john!
__________________
JH

 
The following user gives a hug of support to Unzzz2003:
luyingjie (01-25-2012)
The Following User Says Thank You to Unzzz2003 For This Useful Post:
luyingjie (01-25-2012)
Old 02-01-2004, 11:03 AM   #2
Inactive
(female)
 
Join Date: Nov 2000
Posts: 699
thanbey HB Userthanbey HB Userthanbey HB Userthanbey HB Userthanbey HB Userthanbey HB Userthanbey HB Userthanbey HB Userthanbey HB Userthanbey HB Userthanbey HB User
Re: Higher Enzymes Post Trtment.

Quote:
Originally Posted by Unzzz2003
Hello All; I haven't been here for a while, just got some bloodtest results and wanted to jump in here. I did trtment and stopped responding after 10 months so stopped trtment about 15 months ago. My recent bloodwork now shows my ALT&AST higher than ever before. I used to run in the 80's or so for both, now my ALT is 158 and AST 105 and Viral load which I don't worry about much is back up 16 Million. Just wondering if anyone has gone thru the same thing. I am wondering just how great things truly are after trtment for non-responders, and if things get worse. Thanbey, I think We had started to talk about this when I disappeared for a while. Any input? 2 and a half years ago on biopsy I was Stage 3 Fibrosis as well as Stage 3 inflamation
with moderate piecemeal necrosis and mod. portal infiltrates. Hope All Are doing WELL. Thanks.....Peace.......john!

Welcome back, John.

Your experience is consistent with a trend noted in the FDA approval hearing at the FDA. A non-responder to the interferon treatment may see an increase in fibrosis progression within one to two years post treatment. This may or may not be the case for you. Enzymes are notoriously unreliable predictors.

This is the reason I recommend caution to those without evidence of advancing disease. You have evidence of advancing disease in your biopsy result, and therefore the treatment was worth trying, in my opinion. No genotype responds 100% of the time, so caution is in order for anyone with little or no evidence of progression. Progression is not a "given." And, weird as it sounds, you may have some improvement of the fibrosis. It is information you need to have in order to move forward and make decisions.


At this point, another biopsy may be in order ( possibly with a larger sample of the tissue this time. Size matters!) to answer the fibrosis question and a discussion with your specialist about low-dose interferon-only therapy, intermittant or on-going, or ribavirin-only therapy (which is now being investigated) if there is evidence of further fibrosis or borderline cirrhosis. (Remember there is some subjectivity in the pathology reports , so have the pathologist look at the two biopsy samples on slides and physically COMPARE them to each other, each and every time a biopsy is done. Simply comparing pathology reports or using a rating chart is not going to be through enough.)

There are also clinical trials of longer term, higher dose interferon. This may be an option if you tolerated the interferon well and has no adverse events or risks of same. Consensus interferon is also being discuss more frequently these days. It always had better results in genotype 1's on retreatment and was the only interferon approved for re-treatment. They are working on pegylating it, but it is still available unpegylated (just not aggressively marketed) for those genotype 1's looking at retreatment. Ribavirin is about to be available generically also, I hope.

Everything is an experiment with a non-responder. You have entered the twilight zone of medical knowledge in hepatitis C. But, don't give up or give in. Make sure your lifestyle is pristine and talk over your options with your doctor. Look into clinical trials and weight those opportunities out very carefully. Human experiments are there to answer a question. That means we don't have the answers, yet.

And, last, but not least.............hepatitis C, even at the stage 3 or 4 biopsy, is still a long way from liver failure or a transplant. If you are not eligible for a clinical trial, cannot manage maintenance interferon treatment, there is still NO reason to expect to be incapacitated by hepatitis C. Taking excellent care of yourself and having a postive outlook is still really good medicine. No drug or treatment can compensate for being cavalier about self care.


I hope this helps,

thanbey


hepatitis c outreach project
[url]www.hcop.org[/url]

...all information is intended for general information and is not an attempt to speak to the specifics of any one person's medical situation or decision...........

preapproved by moderator1

 
The Following User Says Thank You to thanbey For This Useful Post:
luyingjie (01-25-2012)
Sponsors Lightbulb
   
Old 02-01-2004, 12:07 PM   #3
Senior Veteran
(male)
 
Join Date: Nov 2000
Location: New York, NY< USA
Posts: 766
sean HB Usersean HB Usersean HB Usersean HB Usersean HB Usersean HB Usersean HB Usersean HB Usersean HB Usersean HB Usersean HB User
Re: Higher Enzymes Post Trtment.

Hi John,

Sorry your news isn't better. Just to add a bit to Thanbey's post, you might want to check out Centerwatch to see if there are clinical trials in your area of pegged cifn, or of one of the newer combos such as thymosin combinations. Most of the clinical trials out there seem to be tailored to non-responders or relapsers, so you might be right up their alley.

T has wanred of the dangers of confusing being part of a trial with being treated. They are different ways of being, and it is important to keep this in mind, but at stage three, you have to weigh these options more seriously than otherwise.

Keep us posted, please.

Peace.


sean

 
The following user gives a hug of support to sean:
luyingjie (01-25-2012)
The Following User Says Thank You to sean For This Useful Post:
luyingjie (01-25-2012)
Closed Thread

Similar Threads
Thread Thread Starter Board Replies Last Post
High Liver Count/Enzymes After Surgery? Galskygge Liver & Pancreas Disorders 2 11-06-2007 08:26 AM
Liver enzymes increased with hyper? osteoblast Thyroid Disorders 9 07-24-2007 09:08 PM
Elevated Liver Enzymes and Pain Meds kim3101 Pain Management 8 06-04-2007 04:15 AM
Effects of prolonged exercise on liver enzymes runner12 Liver & Pancreas Disorders 0 06-14-2005 07:59 PM
ang64063, question about the GNC enzymes.... Shari T Autism Spectrum 1 01-02-2005 07:21 PM




Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off




Join Our Newsletter

Stay healthy through tips curated by our health experts.

Whoops,

There was a problem adding your email Try again

Thank You

Your email has been added








TOP THANKED CONTRIBUTORS



thanbey (425), sean (177), LOST1 (107), Wes1212 (86), Jemah (71), joann jennings (67), churchkp (58), eyesworld (55), glo53 (54), jessy28 (52)

Site Wide Totals

teteri66 (1167), MSJayhawk (1000), Apollo123 (899), Titchou (836), janewhite1 (823), Gabriel (758), ladybud (747), sammy64 (668), midwest1 (665), BlueSkies14 (610)



All times are GMT -7. The time now is 11:58 PM.



Site owned and operated by HealthBoards.comô
Terms of Use © 1998-2014 HealthBoards.comô All rights reserved.
Do not copy or redistribute in any form!