Oil of oregano is quite strong so it might be best to start with only small doses and work up to more. It's recommended to be taken under the tongue with only a few drops at a time.
Some people experience what are referred to as "healing reactions" or die-off effects when starting on the oil. These could be mild such as a general feeling of tiredness or they could be more severe such as intial prolonged H outbreaks, headaches, body aches, acne breakouts, unusual bowel movements, etc. Again, your mileage may vary. Seek a professional's advise if you're unsure about anything you may experience if you decide to try the oil. Good luck.
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