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Old 02-14-2012, 04:44 PM   #1
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positive culture AND negative blood

I was diagnosed with Herpes type 2 with a positive culture and equivocal blood test in November 2011. I just retested about 2 weeks ago (3 months later) and it came back negative. both were done with IGG. my doctor said she doesn't know why there's a discrepancy between my culture test (positive) and my blood test (negative). She suggested I get tested again in 4-6 weeks.

I asked my doctor if my culture could be a false positive...or maybe blood can be false negative....she didn't know. she said she's never really seen this before. Anyone know???

 
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Old 02-15-2012, 05:58 AM   #2
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Re: positive culture AND negative blood

You have your own little timeline going. Actually it does help to narrow down which partner/encounter caused the herpes infection. It takes GENERALLY 3-4 months for your body to produce enough antibodies to be detected in an IgG blood test. Some people less, some people more. One person on this board had positive culture and blood did not show positive until a year later.

A positive culture is basically 100% accurate. The only way it could be wrong is by gross human error by the lab. I.E. they put Mrs. Jones culture into a vial labled Mrs. Smith. Labs have pretty strict protocol to follow for testing so that is rare.

What it can tell you is that you most probably contracted herpes from a recent partner. It is not from someone you dated 1 or 2 years ago because if that was the case, your blood would have tested positive for herpes antibodies.

A postive culture and a negative blood test USUALLY mean you just got this recently. Only you can determine from your sexual life when that might have been. And yes blood tests can show a false negative. There is margin for error in any test. Right now you know you have type 2 and hopefully you know WHERE you have it. (Type 2 can occur in both the oral and genital regions.)

I would wait as your doctor said and get retested but be sure to practice safe sex and inform partners. Your partner should also be tested and future partners should be informed.
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HSV-2 positive. Found out 9-27-07. Flu-like symptom 6-7-07.
Year one outbreaks Sep Oct Nov Dec Apr Jun. Ugh.
Year two outbreaks Dec Apr/May

 
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Old 02-15-2012, 07:12 PM   #3
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Re: positive culture AND negative blood

the last (and old) partner was in november 2011....it was the first time he did oral on me and 1 1/2 days later i had an outbreak. I went straight to the doctor's the next day. I only had one other "new" partner in the last 2 years (august 2011). They were both informed about my situation and had informed me that they were negative as they get tested every 6 months for their own health and safety.

I'm definitely not the type to sleep around (2 partners in 2 years) and that's why this whole thing REALLY SHOCKED me as i've always practiced safe sex, plus i tend to be kinda anal when it comes to std's and germs and such.

what are the odds of the culture being a false positive if it wasn't a human error? Would you suggest the Western blot test?

Thanks for you input. I really appreciate it.

 
Old 02-18-2012, 06:36 PM   #4
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Re: positive culture AND negative blood

If your prior partners said they had std tests and were negative, please be aware that a test for herpes is NOT part of the typical STD panel of tests. You have to specifically ask for that test. So they may think they were tested for EVERYTHING but NOT tested for herpes.
__________________
HSV-2 positive. Found out 9-27-07. Flu-like symptom 6-7-07.
Year one outbreaks Sep Oct Nov Dec Apr Jun. Ugh.
Year two outbreaks Dec Apr/May

 
Old 05-12-2012, 07:05 PM   #5
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Re: positive culture AND negative blood

After another negative blood test in the beginning of April and an infectious disease specialist trying to convince me to go with the culture test result, i requested the Western Blot test. My results says i'm positive for hsv-1, but negative for hsv-2.

anyone experience this before??

 
Old 05-14-2012, 01:51 AM   #6
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Re: positive culture AND negative blood

I'm in a similar situation. I was diagnosed by culture in December, and had the blood test about 10 days ago. My doctor called and left a message at the end of last week and said it was negative, but that that happens. I haven't had a chance to talk to her yet, but I'm wondering if my body hasn't had a chance to build up antibodies because I've been on almost constant anti-virals since my diagnosis. If the medication has been suppressing things maybe my immune system hasn't kicked in all the way? I'm by no means a biology or medical student so I have no idea if that makes sense though. I don't know. Viruses are weird. I'll let you know what I find out from my doctor...

 
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