addicted,
You have to more specific about your numbers (201 is a lot less fearsome than 401).
Sure, a fast weight gain is very likely to screw with your blood fats big time.
It's not likely you'd feel symptoms from the cholesterol but just suddenly forcing your body to lug around an extra 50 pounds is going to change the way you feel IMMENSELY.
Let the doctor check you out and get on some plan to drop that weight again (unless you've just gotten out of a concentration camp

))
Good luck!