Re: Niacin therapy and alcohol consumption
Consumption of alcohol while taking large doses of niacin may also increase the flushing side effect of the niacin.
"The liver undergoes profound changes in both its endoplasmic reticula and its microsomal enzymes in order to detoxify alcohol. The unbalanced introduction of very large doses of niacin to an overloaded liver may well overtax an alcohol-strained system. This is likely where some changes in liver function tests come from (American Journal of Medicine, vol 86, April, 1989, page 431 and vol. 87, August 1989, page 248; American Journal of Cardiology, vol. 64, October 1, 1989 page 728).