Rorie:
From Adventis:
Quote:
Drug Interactions
Although no specific interaction studies were performed, pooled data from clinical trials showed no evidence of clinically significant adverse interactions with uncontrolled concurrent administration of calcium-channel blockers, estrogens, fibrates, NSAIDS,HMG CoA reductase inhibitors, sulfonamides, or thyroid hormone.
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No mention was made of the interaction of ezetimibe with Amaryl.
Use of these sufonyureal drugs is showing evidence of increasing heart disease up to 2.5 times the rate for diet/insulin, so care is required (like getting those triglycerides down.)
Unless he NEEDS to take a statin, maybe something like gemfibrozil, a fibrate, that targets triglycerides might be an alternative to the Zetia. It gets 20-50% reduction in tri's.
The statin and the ezetimibe are not without interactive risks taken together...both are hard on the liver.
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