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Old 12-03-2005, 01:43 PM   #1
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Study: Vitamin C Lowers CRP By 24%

I just came across the results of this study which was carried out last year by the University of California, Berkeley. They found that just 500mg of vitamin C per day resulted in a 24% drop in CRP levels, an inflammation risk marker which many now feel is associated with an increased risk of cardiovascular disease. The significance of this finding was evidently enough to persuade the National Institute of Health to award a grant for further research.

[url]http://www.berkeley.edu/news/media/releases/2004/04/12_vitc.shtml[/url]
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Last edited by ARIZONA73; 12-03-2005 at 01:47 PM.

 
Old 12-03-2005, 02:04 PM   #2
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Re: Study: Vitamin C Lowers CRP By 24%

Sounds good to me Arizona...

I've been taking about 2-3 grams of vitamin-c per day... wonder what the optimal dose for CRP reduction is?

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Old 12-03-2005, 03:21 PM   #3
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Re: Study: Vitamin C Lowers CRP By 24%

Quote:
Originally Posted by HubbleRules
Sounds good to me Arizona...

I've been taking about 2-3 grams of vitamin-c per day... wonder what the optimal dose for CRP reduction is?

HubbleRules

I don't know, but I've been wondering about that myself. They observed a 24% reduction with just 500mg after only two months. Not bad, but I wonder if higher doses would have an even greater effect, especially if taken for longer periods of time. I think the optimal dose would probably vary from one individual to another, since everyone is different. It's possible that one person may require 10 times as much as someone else in order to achieve a similar effect. People's nutritional needs can vary quite considerably, which is why I have so little confidence in RDAs.

By the way, Hubble, if you want to read something interesting, Mike Ciell, a registered pharmacist, wrote an article called "One pharmacist's view of coronary heart disease: comparing the Lipid Theory with the Unified Theory."
I'm not sure if I could post that link here, but if you just type Mike Ciell into your browser, you should come across this article with no trouble. It's pretty interesting.
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Old 12-03-2005, 03:32 PM   #4
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Re: Study: Vitamin C Lowers CRP By 24%

Quote:
Originally Posted by ARIZONA73
Vitamin C Lowers CRP By 24%.
I've also read peer-reviewed journal studies that suggest vitamin C doses provide such antioxidant effects (I'll post some of them later).

Now, if I were a conspiracy theorist, I would ask, "Are the orange juice companies funding this research?" Or, "Did the orange juice companies buy out the study parties involved?" Nah, that's not like me. I have no such thoughts!

Last edited by mg_health; 12-03-2005 at 03:32 PM.

 
Old 12-03-2005, 03:56 PM   #5
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Re: Study: Vitamin C Lowers CRP By 24%

Quote:
Originally Posted by mg_health
I've also read peer-reviewed journal studies that suggest vitamin C doses provide such antioxidant effects (I'll post some of them later).
Thanks, I'll be looking forward to reading them.
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Old 12-03-2005, 04:22 PM   #6
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Re: Study: Vitamin C Lowers CRP By 24%

Quote:
Originally Posted by mg_health
I've also read peer-reviewed journal studies that suggest vitamin C doses provide such antioxidant effects (I'll post some of them later).

Now, if I were a conspiracy theorist, I would ask, "Are the orange juice companies funding this research?" Or, "Did the orange juice companies buy out the study parties involved?" Nah, that's not like me. I have no such thoughts!
Only thing U need to be careful of with juice, is alot of them have sugar in them. I'm not a big OJ fan, but drink it every so often. Cranberry juice is suppose to be good for you, yet they say it has the highest amount of sugar. I swear, no matter what is good for you, it has a drawback of some kind. Here is part of an article I found:

Watch the sugar - Juices have natural sugars in them, without the fiber that would buffer the blood sugar reaction if you were eating the whole fruit. One glass of orange juice can have the juices of 2 or 3 oranges, depending upon size, and all that sugar can hit your bloodstream at once. Ideally, juice should be drunk with a meal containing protein and a high-fiber food such as oatmeal or vegetables.

Oh well, like I said, seems at times it is a losing battle.........

 
Old 12-03-2005, 04:48 PM   #7
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Re: Study: Vitamin C Lowers CRP By 24%

Quote:
Originally Posted by JJ

Oh well, like I said, seems at times it is a losing battle.........

That's why God invented alchohol!!!


HubbleRules

 
Old 12-03-2005, 04:52 PM   #8
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Re: Study: Vitamin C Lowers CRP By 24%

Quote:
Originally Posted by HubbleRules
That's why God invented alchohol!!!


HubbleRules
Well I guess I will just have to try and teach myself not to get drunk just smelling the cork......

Geez, didn't I say I had a dishwasher to load? This CRS is out of hand!!

Have a good one, and TTYL...

 
Old 12-03-2005, 05:01 PM   #9
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Re: Study: Vitamin C Lowers CRP By 24%

Quote:
Originally Posted by HubbleRules
Sounds good to me Arizona...

I've been taking about 2-3 grams of vitamin-c per day... wonder what the optimal dose for CRP reduction is?

HubbleRules
Optimal dose is up to Bowl intolerance!! Most people thats usually 10 gms daily. harry!

 
Old 12-03-2005, 05:45 PM   #10
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Re: Study: Vitamin C Lowers CRP By 24%

I noticed in this study that they had two groups - one taking 500mg vitamin c, another taking a mixture of vitamin-c, vitamin-e and alpha-lipoic acid.

The group taking a mixture only had a 4.7% reduction in CRP.

I wonder if that means we should take our vitamin-c and vitamin-e at different times of the day, or on separate days?

HubbleRules

 
Old 12-03-2005, 05:57 PM   #11
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Re: Study: Vitamin C Lowers CRP By 24%

Quote:
Originally Posted by ARIZONA73
Thanks, I'll be looking forward to reading them.
Here you go - journal studies showing various cardiovascular benefits of vitamin C (ascorbic acid) intake:

Vitamin C and risk of coronary heart disease in women.
http://www.ncbi.nlm.nih.gov/entrez/q...759&query_hl=2

Effects of certain micronutrients and melatonin on plasma lipid, lipid peroxidation, and homocysteine levels in rats.
http://www.ncbi.nlm.nih.gov/entrez/q...094&query_hl=2

Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts.
http://www.ncbi.nlm.nih.gov/entrez/q...762&query_hl=2

AZT induces oxidative damage to cardiac mitochondria: protective effect of vitamins C and E.
http://www.ncbi.nlm.nih.gov/entrez/q...479&query_hl=2

Avenanthramides and phenolic acids from oats are bioavailable and act synergistically with vitamin C to enhance hamster and human LDL resistance to oxidation.
http://www.ncbi.nlm.nih.gov/entrez/q...412&query_hl=2

Vitamin C intake and risk of ischemic heart disease in a population with a high prevalence of smoking.
http://www.ncbi.nlm.nih.gov/entrez/q...929&query_hl=2

Cardiovascular effects of oral Supplementation of vitamin C, E and folic acid in young healthy males.
http://www.ncbi.nlm.nih.gov/entrez/q...811&query_hl=2

Oral vitamin C ameliorates smoking-induced arterial wall stiffness in healthy volunteers.
http://www.ncbi.nlm.nih.gov/entrez/q...590&query_hl=2

Decreased plasma and tissue levels of vitamin C in a rat model of aging: implications for antioxidative defense.
http://www.ncbi.nlm.nih.gov/entrez/q...843&query_hl=2

Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia.
http://www.ncbi.nlm.nih.gov/entrez/q...643&query_hl=2

Improvement of sympathetic response to exercise by oral administration of ascorbic acid in patients after myocardial infarction.
http://www.ncbi.nlm.nih.gov/entrez/q...442&query_hl=1

Stannous chloride induces alterations in enzyme activities, lipid peroxidation and histopathology in male rabbit: Antioxidant role of vitamin C.
http://www.ncbi.nlm.nih.gov/entrez/q...410&query_hl=2

Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
http://www.ncbi.nlm.nih.gov/entrez/q...504&query_hl=2

Acute effect of oral vitamin C on coronary circulation in young healthy smokers.
http://www.ncbi.nlm.nih.gov/entrez/q...000&query_hl=2

Genomic effect of vitamin 'C' and statins within human mononuclear cells involved in atherogenic process.
http://www.ncbi.nlm.nih.gov/entrez/q...944&query_hl=2

Flavonoids from almond skins are bioavailable and act synergistically with vitamins C and E to enhance hamster and human LDL resistance to oxidation.
http://www.ncbi.nlm.nih.gov/entrez/q...439&query_hl=2

Ascorbic acid selectively improves large elastic artery compliance in postmenopausal women.
http://www.ncbi.nlm.nih.gov/entrez/q...135&query_hl=2

Health effect of vegetable-based diet: lettuce consumption improves cholesterol metabolism and antioxidant status in the rat.
http://www.ncbi.nlm.nih.gov/entrez/q...097&query_hl=2

Frequency of fruit and vegetable consumption and coronary heart disease in France and Northern Ireland: the PRIME study.
http://www.ncbi.nlm.nih.gov/entrez/q...259&query_hl=2

Impairment of coronary circulation by acute hyperhomocysteinaemia and reversal by antioxidant vitamins.
http://www.ncbi.nlm.nih.gov/entrez/q...475&query_hl=2

Vitamin C inhibits hypoxia-induced damage and apoptotic signaling pathways in cardiomyocytes and ischemic hearts.
http://www.ncbi.nlm.nih.gov/entrez/q...281&query_hl=2

Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction.
http://www.ncbi.nlm.nih.gov/entrez/q...746&query_hl=2

Cardiotoxicity in rats induced by methidathion and ameliorating effect of vitamins E and C.
http://www.ncbi.nlm.nih.gov/entrez/q...849&query_hl=2

Increased F2 isoprostane plasma levels in patients with congestive heart failure are correlated with antioxidant status and disease severity.
http://www.ncbi.nlm.nih.gov/entrez/q...701&query_hl=2

Effects of antioxidants on coronary microvascular spasm induced by epicardial coronary artery endothelial injury in pigs.
http://www.ncbi.nlm.nih.gov/entrez/q...617&query_hl=2

Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men.
http://www.ncbi.nlm.nih.gov/entrez/q...830&query_hl=2

Improvement of peripheral endothelial dysfunction by acute vitamin C application: different effects in patients with coronary artery disease, ischemic, and dilated cardiomyopathy.
http://www.ncbi.nlm.nih.gov/entrez/q...196&query_hl=2

A mixed fruit and vegetable concentrate increases plasma antioxidant vitamins and folate and lowers plasma homocysteine in men.
http://www.ncbi.nlm.nih.gov/entrez/q...177&query_hl=2

In Vitro and In Vivo Lipoprotein Antioxidant Effect of a Citrus Extract and Ascorbic Acid on Normal and Hypercholesterolemic Human Subjects.
http://www.ncbi.nlm.nih.gov/entrez/q...400&query_hl=2

Combined vitamin C and E supplementation retards early progression of arteriosclerosis in heart transplant patients.
http://www.ncbi.nlm.nih.gov/entrez/q...519&query_hl=2

 
Old 12-03-2005, 08:03 PM   #12
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Re: Study: Vitamin C Lowers CRP By 24%

Quote:
Originally Posted by HubbleRules
I noticed in this study that they had two groups - one taking 500mg vitamin c, another taking a mixture of vitamin-c, vitamin-e and alpha-lipoic acid.

The group taking a mixture only had a 4.7% reduction in CRP.

I wonder if that means we should take our vitamin-c and vitamin-e at different times of the day, or on separate days?

HubbleRules
Yes, but did you notice that they also said the following:

"The researchers noted that in other studies, higher doses of vitamin E produced lower CRP levels among type 2 diabetics and healthy individuals."

In the vitamin C study, there was no mention of what dose of vitamin E was used.
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Old 12-03-2005, 08:07 PM   #13
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Re: Study: Vitamin C Lowers CRP By 24%

Thanks for that information, Mg Health. By the way, how do you find these studies so quickly?
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Old 12-03-2005, 08:15 PM   #14
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Re: Study: Vitamin C Lowers CRP By 24%

Hubble, have you had the chance to read Mike Ciell's article yet?
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Old 12-04-2005, 03:11 AM   #15
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Re: Study: Vitamin C Lowers CRP By 24%

Well I eat a ton of veggies and fruit that contain Vitamin C and also take 1000 mgs a day in supplement and still my CRP is at heart attack/stroke risk. Someone once said to me that if I had a strenuous workout the night before bloodwork that would cause the CRP to go up. Well I have those all the time so I'm wondering is CRP really what it seems to be? Lisa

 
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