All,
I was just reading today in the New York Times that it's been revealed that Merck has conducted several trials of Zetia, used in combination with Statins, that raise questions about it's effect on the liver, but never published those studies.
Also, in the ENHANCE trial that they did publish, and which the FDA relied upon in approving the drug, some people who developed liver problems during the trial were dropped from the trial and their results excluded from it - and this fact was never included in the study results.
The article stated that studies have indicated that taking Zetia in combination with a Statin results in an 11 times greater chance of health problems than taking a Statin alone.
Canada has explicit warnings on Zetia and Vytorin notifying people of the potential for liver damage - but the FDA does not require these warnings on the drugs sold in the U.S.
Just a word of warning...
HubblRules