You have asked me this once before, which I thought that I had already answered.
Basically, there were centuries prior to medication for known Hypercholesterolaemia.......and only a couple of decades since.
There have also been centuries of documented Hypercholesterolaemia cases and studies.
Being in Europe, I suppose our libraries hold older archives than those of the States.
The most mentioned figure I have read is the TC figure of 160mg/dl. Below this 'line', is considered....too low, whether on or off medication.