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Old 10-21-2004, 04:49 PM   #1
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strong_one HB User
Went to GP and she insists on only one drug - please advise.

At least out of the visit I got a referral to get an echocardiogram and 24 hours BP monitor. My BP was 154/98. I told her that my Avalide wasn't bringing it down and that I took my BP meds in the morning at 6:00 and that's the lowest I could bring it down with that med in 3 hours. Ridiculous.

Anyway, I urged her to let me try the same one my Mom and Husband use - Lisinopril at 20mg. Has anyone used that and not had any complications?

 
Old 10-22-2004, 04:10 PM   #2
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Re: Went to GP and she insists on only one drug - please advise.

Lisinopril is a good bp med that will bring you bp dowm significantly. it does have side effects. Im allergic to lisinopril and had to stop taking it. It cause a cough. I had many other problems with it.

 
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Old 10-25-2004, 06:06 AM   #3
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Re: Went to GP and she insists on only one drug - please advise.

girlofsteel,

It all hinges on whether you get "the cough" or not. If you do, it's unlikely you will be able to bear it more than a month or so.

If you like it, maybe you should consider the additional avalide a waste of money because the two drug classes are similar...basically one blocks ACE production and the other blocks attachment. Something like lisinopril and separate HCTZ might be a better choice.
(The Avalide provides HCTZ)

Bet you cough though...non coughers seem to be in the minority!

 
Old 10-25-2004, 06:36 AM   #4
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Re: Went to GP and she insists on only one drug - please advise.

Quote:
Originally Posted by zip2play
girlofsteel,

It all hinges on whether you get "the cough" or not. If you do, it's unlikely you will be able to bear it more than a month or so.

If you like it, maybe you should consider the additional avalide a waste of money because the two drug classes are similar...basically one blocks ACE production and the other blocks attachment. Something like lisinopril and separate HCTZ might be a better choice.
(The Avalide provides HCTZ)

Bet you cough though...non coughers seem to be in the minority!
Actually, the two classes are not all that similar.

The ACE inhibitor does two things. It reduces angiotensin II (a vasoconstrictor) and increases bradykinin (a vasodilator). Both of these actions reduce blood pressure. However, this very same bradykinin is what causes the cough. Therefore, the folks who have the cough are probably the same ones who are most likely getting the best BP results from ACEIs. Also, since the body has other (non ACE) means of producing angiotensin II, they are not very efficient at this mechanism.

ARBs exclusively block the actions of angiotensin II. Bradykinin remains at the same level. Therefore, no cough. And, no blood pressure lowering effects from this mechanism either. However, they are much more effective at reducing the vasoconstriction effects of angiotensin II. So, they only reduce BP by one mechanism. But, they do it with greater efficiency.

Pal

 
Old 10-25-2004, 08:40 AM   #5
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Re: Went to GP and she insists on only one drug - please advise.

I did get the cough, but mine was gone in about a week. Keep your fingers crossed.

 
Old 10-25-2004, 11:13 AM   #6
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Re: Went to GP and she insists on only one drug - please advise.

I got the cough, but i think it was also do to smoking. i could tolerate the cough, it was the other side effects i had a problem with. Then the drs discovered i was allergic to ace and arbs.

 
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