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Originally Posted by Catalina_FLA I have noticed since I am on the enalapril though that I seem to be sodium sensitive now. |
Yep, I think this is true for pretty much anyone on an ACE inhibitor or ARB. I noticed the same thing on Benicar. I normally eat relatively low sodium (not totally millitant about it, though). Before drugs, I tried cutting out sodium to lower my BP to avoid drugs. Nothing, nada, zip change in BP. When I started Benicar, I was still eating low-sodium. Wow, Benicar is working awesome. I guess I can eat tons of sodium now. WRONG! If I eat out at certain places my BP will almost return to where it was before the meds for about 2-3 days. Then, I started researching about this. And, it all makes sense now.
I think it all comes down to volume. When we lower our sodium intake, we have a feedback mechanism that causes our blood vessels to constrict to compensate. So, it is impossible for most of us to lower our BP with a low sodium diet. However, the ACE/ARB blocks this feedback and makes us "salt-sensitive" so we can lower our BP by reducing sodium.
Again, I still find the 1978 experiment on dogs to be the most interesting article on this subject. Here is the URL: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=372606 . It's interesting for several reasons. First, it was done in 1978. We knew about this before these drugs were even available. Second, we keep reading about all this worthless salt nonsesense all over the place with no mention of renin-angiotensin feedback system that comes into play. I remember reading in some other studies how sodium restriction seemed to only make a difference in the hypertensive population. Well, duh, many of those hypertensive people are taking ACEI and ARBs.
Oh well, enough about this. I've stated this before in many threads.
Pal