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Old 12-03-2004, 10:04 PM   #1
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Any thoughts/comments!!

Hello all;
I am trying to understand what is the difference bwtween the concentration/dosage of medications. For example, what is the difference bwtween Diovan 80 mg and Diovan 160 mg and their effect on the body? I know that Diovan 160 mg would work twice stronger than the Diovan 80 mg on the body? But does that mean the side effects would be doubled if any?
Any thoughts/comments!!
Thank you

 
Old 12-04-2004, 01:53 AM   #2
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Re: Any thoughts/comments!!

Waheshny,

Very often, side effects in response to a particular drug, are indeed dose-related. If 80mg produces side effects, doubling it will almost surely make things worse. But also, while 80 mg of Diovan may not produce any adverse reactions, 160mg might.

Still, generally, if you tolerate a drug well at a lower dosage, but it isn't quite doing enough to control your blood pressure, chances are you may not have any problems whatsoever upping the dose and getting good BP control into the bargain!

zuzu xx

 
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Old 12-04-2004, 03:36 AM   #3
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Re: Any thoughts/comments!!

One other thing I would like to add is that for most drugs (ACEs and ARBs in particular), you get most of the BP lowering effect at the lower dose. For instance, assume that 80 mg lowers your BP by 15 points. If you were to double the dose to 160 mg, it might lower it by 17 points - not by 30 points. As you continue to double, the additional effect becomes less and less. BTW, ARBs are a very poor choice for a suicide attempt. If you were to take the whole bottle, it probably wouldn't do much more to your BP than taking a single pill.

Pal

 
Old 12-04-2004, 12:38 PM   #4
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Re: Any thoughts/comments!!

ARBs are a very poor choice for a suicide attempt. If you were to take the whole bottle, it probably wouldn't do much more to your BP than taking a single pill.

<puts all the pills back in the bottle>
Couldn't resist

 
Old 12-04-2004, 02:32 PM   #5
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Re: Any thoughts/comments!!

Pal,

I must be an ARB user who doesn't fall into the "norm".

When first Dx'd, untreated my BP was at times 180's/98. We monitored for a few months. It was sometimes lower but rarely below 160's/90's. Pretty labile but up there.

On 80mg Diovan we brought it down to 140/90 but couldn't budge it lower.
On 160mg- I got (and still maintain) 110'ish/high 60's-70!

zuzu xx

 
Old 12-06-2004, 06:23 AM   #6
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Re: Any thoughts/comments!!

I agree with Palamedes. The higher dosage doesn't bring it down that much more. If anything I think that it just increases the side-effects.

 
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