There seems to be a stong implication here that ACE and ARB method drugs don't do much except in the presence of salt deprivation.
These systemic and coronary vasodilator effects of teprotide and saralasin, however, were not observed in normal dogs on a regular sodium diet
from the abstract.
The study seems to be talking AROUND that inevitablility...it's a tough day, so I could be getting the "wrong end of the stick."
This I found the most intersesting (from page 880):
Teprotide produced no systemic hemodynamic effects |
in normal dogs, suggesting that the reninangiotensin
system plays no important role in maintaining
arterial blood pressure in dogs on a regular
sodium diet. In contrast, arterial blood pressure
increased transiently in normal dogs during saralasin
infusion, probably because of the partial agonist effect
of saralasin. These results also indicate that neither
agent has primary vasodepressor effects in normal dogs,
and that the vasodilation produced by both agents in
sodium-depleted dogs probably is related to the high
angiotensin II level. Nevertheless, it may still be
possible that a primary drug-induced vasodilation may
occur during sodium depletion.
That implies you almost must have BOTH together, i.e., ain't HYZAAR a good idea. Another implication might explain why ACE's and ARB's alone aren't wonder drugs.
P.s. the article, while excellent STILL gives me a headache!