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Old 01-08-2005, 06:35 PM   #1
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Question Another Diovan Question

Is anyone out there taking diovan 320? If so, how has it been tolerated. I am on diovan 160 and i take a hctz (12.5) every other day. Have been taking this combo for over a year now but my pressure could be better. Lately i have been getting readings of 140/150 over 75/85. I am afraid my dr will want to introduce another medication (at first i was on a beta blocker and i did not like the way i felt). Although i initally had some symptoms from the diovan (lightheadedness and tiredness) I seem to tolerate it much better now. I would like to stick with an ARB even if it is stronger, rather than introduce another class of drugs..Any input would be greatly appreciated

 
Old 01-08-2005, 06:52 PM   #2
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Re: Another Diovan Question

I'm a big fan of Diovan so I know what you mean when you say you'd like to stick with it. I take 160mg myself. Not sure how much more control you can get on a higher dose.

How about trying the HCTZ every day instead of every other day?

zuzu xx

Last edited by zuzu8; 01-08-2005 at 06:54 PM.

 
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Old 01-08-2005, 08:45 PM   #3
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Re: Another Diovan Question

Thanks for the reply...for some strange reason when i took the hctz every day I did not feel that well - when we tried it this way i did much better and the readings did not change at all. I just thought the higher dose might reduce the BP even more. Why do they make it in 3 different strengths???

Last edited by ad630; 01-08-2005 at 08:48 PM.

 
Old 01-09-2005, 02:13 AM   #4
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Re: Another Diovan Question

If a daily dosage of HCTZ made you feel punk, then by all means, discuss with your doctor the idea of increasing the Diovan.

First, though, titrate up by 80mg...no need to double it yet.

Your #s are borderline...so that extra 80mg might be just the boost you need.

zuzu xx

 
Old 01-09-2005, 06:53 AM   #5
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Re: Another Diovan Question

ad,

Here's what Novartis says about the expected effect of the increase: (Damn, I can't seem to copy from the PDF!)

Oh well, a'typin we will go:

Quote:
Doses of 80, 160 and 320 mg. produced dose-related decreases in systolic and diastolic blood pressure, with the difference from placebo of approximately 6-9/3-5 mmHg at 80-160 mg, and 9/6 mmHg at 320.
So there's SOMETHING to be gained from going to 320 but it's really only a couple points. You'll get more bang for your buck if you add a second drug (sorry!)

 
Old 01-09-2005, 10:50 AM   #6
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Re: Another Diovan Question

Lenin,

On the other hand, Novartis' monograph notwithstanding, my personal experience with Diovan is astounding.

Untreated BP- 160's-180/high 90's
On 80mg----- 140's/90
On 160mg------98-113/65-70

I know, I know, this is all anecdotal on my part and you probably think I practice voodoo ... but it just goes to show it can happen!

zuzu xx

 
Old 01-09-2005, 11:35 AM   #7
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Re: Another Diovan Question

I think what happens with these drugs is that there is a critical dose to get a therapeutic response. Once you get there, increasing the dosage doesn't make any difference. However, if the dose is inadequate, it doesn't work. It's more like a binary thing. It's either working or not.

Pal

 
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