Re: Any input on Thiazide Lisinopril combo?
The combo is particularly effective for the following reason. When you take a diuretic to deplete your body of sodium and water, your kidneys produce the hormone RENIN which causes the eventuual production of Angiotensin-2 a very potent pressor (raises BP) agent. Among other things, angiotensin squeezed down on small arterioles to raise BP, thus battling the effects of the diuretics.
So an ACE inhibitor stops the conversion of angiotensin to angiotensin-2 and prevents the feedback allowing the BP to stay down.
The reverse feedback happens with just the ACEI because more aldosterone is produced by the adrenals and sodium is retained and thus the effect of the relaxed arterioles and lowered BP is countebalanced by water retention and higher BP. The thiazide (or severe salt restricition) prevents the feedback loop!
I would go so far as to say "you can't have one without the other" and in a less tuneful way that these two drugs are really ideal mates for those people who don't have a lot of luck with severe salt restricted diets. That's why there are so many ACEI-HCTZ combos. I wish I could take an ACEI but alas, THE COUGH!
Last edited by Lenin; 07-20-2005 at 06:49 AM.