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High & Low Blood Pressure Message Board
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Old 03-07-2006, 07:55 PM   #1
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Can the body become tolerant of Atenolol and Lisiniprol?

I was put on Atenolol instead of dueretic HTZT because I was dehydrating too easy. Now I'm on 20 mg of Lisiniprol a day and a small amount of that Atenolol, 10 mg, roughly, can't remember how much but it's a light dosage- but anyway, can I develop a tolerance (undesirably) to a point that the medicine will lose it's effects?
I'd imagine it take as long as it did to get high BP, over time, but can I still smoke or chew and eat how I have been, not cautious of salty foods and still will the medicines keep their effects or will I ask for more trouble and need stronger doses of these?
I'm hoping not, but just wondered. MY BP is now a nice 112/72 ranging to 120/79 and the other day was a nice 110/68 with a pulse of 60, pulse also was 66, and a 77 when i was up doing stuff all day. I'm also trying to trim and tone at the gym by running, I heard it's the fastest way to burn calories, and get that aerobic benefit the heart needs is to run. When I'm in motion running they have a heart rate machine and its like 152 a minute but their chart says I need to be at 172 a minute, does this mean the heart is desired to beat faster when working and slower at rest? I'm a 30 yr old male, 5' 10" about 28 to 33 lbs over my MBI weight.
Just some things I'd like to know if someone know a bit of it. Thanks all.

 
Old 03-08-2006, 05:59 AM   #2
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Re: Can the body become tolerant of Atenolol and Lisiniprol?

A tolerance to atenolo...not so much.

A tolerance to any ACE inhibitor like lisinopril... hightly likely to begin after 6 months.

It's a shame because the ACE inhibitors are good drugs if you can take them and are a Renin hypertensives.

 
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Old 03-08-2006, 09:25 PM   #3
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Re: Can the body become tolerant of Atenolol and Lisiniprol?

I was kind of wondering and didn't want the inevitable but yeah, I was on like 10 mg of lisinoprol alone, then had to goto 20mg once daily.
Thanks, will just have to eat more fruits and veggies and watch my salt and quit the tobacco. Sounds like I'm losing all the fun out of life already but I'm sure it gets better. lol

 
Old 03-09-2006, 03:23 AM   #4
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Re: Can the body become tolerant of Atenolol and Lisiniprol?

Quote:
Originally Posted by Lenin
A tolerance to any ACE inhibitor like lisinopril... hightly likely to begin after 6 months.
Really? Didn't the ALLHAT study show continued efficacy of lisinopril after 5 years of use?

 
Old 03-09-2006, 06:56 AM   #5
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Re: Can the body become tolerant of Atenolol and Lisiniprol?

Rigel,

It is thought that ACE is responsible for only a portion of the conversion of Angiotensin to Angiotensin-2. A large part (perhaps 40%) is converted by chymases and other enzymes...some estimates for diabetrics is that chymases are the LARGEST component enzyme.
The human body being what it is, when the ACE pathway is cut off, more and more chymase plays a role in more Angiotensin-2 production.
Probably the only thing that can be done is to increase the ACEI dosage.

I'm DYING with the flu and confronting ALLHAT this morning with a goal of finding the dosing procedure with lisinopril is more than this mortal coil can handle. Maybe they upped the dosage as necessary to achieve certain blood pressure goals?

Anyhoo, if you want to read up on it, just follow the word CHYMASE.

Last edited by Lenin; 03-09-2006 at 06:56 AM.

 
Old 03-09-2006, 10:37 PM   #6
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There's herbal remedies too for high Blood Pressure...

please share.
I've found herbal remedies such as Kelp and medicine through food goes a long way.
I love garlic and I swear that stuff is so strong you can feel it burning as you eat it, just imagine that in the blood stream; be like Drano to those arterial plumbing pipes.
:O)
So it's the arteries that play the role for the blood pressure, not the veins?
I noticed doing alot of weights throughout my life i have veins as thick as a garden hose in some places. Can't figure out why the HBP, but oh well.


I'm making an effort to not letting Lisinoprol lose its effects.
Hopefully no need for 40mg. Yikes!
Sounds like alot of milligrams to have to take.

 
Old 03-10-2006, 07:24 AM   #7
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Re: Can the body become tolerant of Atenolol and Lisiniprol?

To be precise, it's the ARTERIOLES that regulate the blood pressure. These are the tiniest of arteries (as small as the finest human hair) that can clamp down with teeny muscles and raise BP sky high. Once the blood leaves the arterioles it's in the low pressure world of the capillaries. Veins and even arteries have very little to do with blood pressure.

 
Old 03-12-2006, 03:37 AM   #8
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Re: Can the body become tolerant of Atenolol and Lisiniprol?

With regards to your question 'can the body become tolerant to atenolol'.........yes i believe it can. I have been on it- various doses now 50mg a day - for 15 years or so and now it doesnt have any control over my BP whatsoever but when i try and come off it i get major withdrawal problems. I have had to start another BP medication which has my BP well under control and we are trying to get me off the atenolol but my body does not like that decision!

 
Old 03-12-2006, 06:15 AM   #9
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Re: Can the body become tolerant of Atenolol and Lisiniprol?

sporti,

It sounds like your adrenals have learned to make much more epinephrine and norepinephrine to compensate for the blockade. I guess that's why weaning from beta-blockers is so important. After 15 years take the wean SLOWLY! It will be a while of higher numbers until your adrenals get back to normal.

I always wonder about this downside of "anything" blockers: beta, calcium channel and even angiotensin receptor. Whenever you "block" a process, the body seems to work harder at accomplishing its goal...and there always seems to a price to be paid, EVENTUALLY!

Last edited by Lenin; 03-12-2006 at 06:20 AM.

 
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