First symptom of the overuse of amphetamines is typing in an extremely large, bold font...
But seriously, YES: ampletamines will increase your metabolism, decrease your appetite, cause your heart to race and increase your blood pressure...a lot.
Taken to extreme, amphetamine addiction will also cause neuroses and frank phychoses with voices and visions.
It's bad for the heart and its probably WORST side effect is a large increase in hemorrhagic stroke risk.