Re: How long does it take for Hctz to work?
Give it a week especially if there is a lot of edema to expel.
For edema, 25 mg./day is a VERY small dose.
I recommend 50 mg./day.
Sometimes it's given in a large dose (+100 mg.) twice a week when used for edema control.
An alternative, maybe even a bit better for edema, is a loop diuretic like Lasix. If the thiazide doesn't do the trick, consider switching to twice daily dosing with 40 mg. Lasix.
But in the meantime, why not call your doctor and ask him to up yout HCTZ Rx to 50 mg./day?
P.S. Thiazide controls BP in two ways: water dumping and arteriole relaxation. That latter effect takes several weeks of daily dosing to begin kicking in.