I'm not sure what the consequences of high dose irbesartan are but I firmly believe that the right dose is the one that gives an AVERAGE rested reading of under 140/90.
Maybe someone like you with kidney damage might aim for lower, say 135/85?
I'm not all that familiar with irbesartan, but I have read a lot about losartan (because I take it.

) A good study showed that there was no greater BP lowering with 100 mg./day than with 50 mg...so I split the pills and take the 50's.