I was just wondering if anyone had an idea. I ran out of my progesterone cream about 3 weeks ago and am still taking estrogen. I have been feeling really lousy lately, irritable, feelings of sadness, not wanting to go anywhere, do anything, almost a feeling of homesickness. Can not taking progesterone along with estrogen cause any of these feelings? I also take an antidepressant but it doesn't seem to be working as good as it should be. If anyone has any thoughts, I would like to hear!