Re: HPV and Indole 3 Carbinol??
I suggest that you take 3,3'-Diindolylmethane (DIM) instead of Indole-3-carbinol since Indole-3-carbinol is the precursor of DIM.
Indole-3-carbinol dimerizes in acid environment of your stomach to become DIM in your body. I also read that DIM is superior to I3C because of bioavailability.
If you have questions regarding DIM, you can always go to pubmed.gov and type in DIM and cervical dysplasia. You'll find scientific articles on DIM and cervical issues from the National Library of Science website.
There are randomized, controlled, double-blind phase III clinical trials on DIM.
Here are some things I read about DIM and I3C:
1. DIM inhibits the development of E6/E7 oncogene-induced cervical lesions.
2. I3C have been implicated in a variety of anticarcinogenic mechanisms, but deleterious effects also have been reported in some experimental protocols, including tumor promotion over prolonged periods of exposure (there are contradictory results on I3C and DIM, and I3C can be toxic so don't take it for a long time, some say DIM shows no toxicity, talk to your doctor).
3. Some studies indicate that dietary I3C prevents the development of estrogen-enhanced cancers including breast, endometrial and cervical cancers by inducing apoptosis of cancer cells(cell death) in vitro.
None of these published papers are really prestigious in my opinion, but I think taking DIM won't hurt. Why not? I'm considering taking it.
Also Folic Acid supplements are supposed to be good for cervical dysplasia.
Some argue that beta-carotene is good for cervical dysplasia, but I also read papers claiming that it has no effect.
IMO, if it's not deleterious, there is no harm in taking vitamin supplements for low grade cervical dysplasia. Consult your doctor.
BTW, none of these results are conclusive. Take them with a grain of salt. Don't believe anecdotal evidence either.
Last edited by Noria; 03-14-2010 at 11:30 AM.