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Old 07-20-2007, 06:26 PM   #1
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salamandertom HB User
autoimmune enteropathy?

Does anyone know what this is or means? A pedi GI mentioned that if my son still has chronic inflamation after being Gluten free for 6 months they should think about this. (they suspect celiac's disease but the diet isn't working)
Thank you so much for any information at all.

 
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Old 09-13-2007, 06:35 PM   #2
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haileesnana HB User
Re: autoimmune enteropathy?

My 3 month old grandson was just diagnosed with autoimmune enteropathy in Atlanta. Are you still wanting information, or were you able to get your child tested? He was diagnosed with a blood test sent to Pa. It took quite a while to get results and the test is done with a very special microscope.

 
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Old 09-13-2007, 08:19 PM   #3
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Re: autoimmune enteropathy?

Yes, it's when the body attacks the small intestine as if it's a foreign body. The bone marrow is actually what does the "attacking." When the intestine is being attacked, the villi are destroyed, causing secretory diarrhea. It's thought that something triggers autoimmune enteropathy. What triggers it is probably something different in each case.
My son was just diagnosed with AIE at the age of 14 weeks.

Quote:
Originally Posted by salamandertom View Post
Does anyone know what this is or means? A pedi GI mentioned that if my son still has chronic inflamation after being Gluten free for 6 months they should think about this. (they suspect celiac's disease but the diet isn't working)
Thank you so much for any information at all.

 
Old 09-15-2007, 10:58 PM   #4
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angela72 HB User
Re: autoimmune enteropathy?

My daughter was diagnosed with this 10 years ago - she is now 17. We have gone through so much with this disorder - and they have NEVER been able to pinpoint why. We just recently started Remicade IV therapy. Hopefully this will help her - but we are now trying to get SSDI for her. It is believed to be very rare - affects less than 200,000 in US? That's what I understand.

 
Old 09-16-2007, 11:50 AM   #5
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cottonsocks HB User
Re: autoimmune enteropathy?

An immune response is the body's defence to anything from outside the body (non-self) which may harm it. The word Autoimmune ( Auto=Greek= Self) is an abnormal immune response to *self *. Autoimmunity only occurs in people who are genetically predisposed to autoimmunity, rather than a specific disease. In other words they genetically carry the "predisposition" rather than the particuilar autoimmune disease. A person who has this, can have more than one autoimmune disease going on at the same time, and another family member have a totally different autoimmune disease. Again the predisposition may not have manifested in the family for generations (as in my own case), but somewhere in the past certain people in my family will have suffered with (any) autoimmune disease.

Enteropathy, means a disease of the intestinal tract. Any part of the inner body which comes into contact with the outside, such as the gut, has secretions which carry antibody. Antibodies are the "soldiers" of the defence system. In a predisposed person the autoimmune response can be stimulated, idiopathically= Spontaneous and for no reason, or by Gliadin =(wheat, the only food scientifically proven in the past 50 years, out of the endless food chain to stimulate a specific autoimmune disease) drugs and radiation. These are often referred to as enviromental factors. Fluids say from severe injury to the eye if leaked internally could also stimulate this response.

Autoimmune enteropathy is where there is gut disease caused by abnormal antibody in the gut. The autoimmune disease may have been stimulated by Gluten (gluten enteropathy) or by a dysfunction of the normal cell processes of the gut. The autoimmune response, produces abnormal antibodies called autoantibodies, and these autoantibodies target normal proteins in the body, causing damage to the tissues, as the autoantibody attacks and tries to destroy *self* tissues.

Quote from tiffani9 = "The bone marrow is actually what does the "attacking."

Well not really the bone marrow exactly.
All cells come from stem cells in the bone marrow. There are three main groups of cells which make up the immune system, and antibodies are are made in turn from one of these 3 groups called lymphocytes. These are white blood cells, and these fall again into two categories, B lymphocytes (which are made in the bone marrow, and produce the antibodies and T lymphocytes which are made in the thymus and can kill antigens directly. Antibodies (Immunoglobulins) fall into 5 groups IgA, IgG, IgM, IgE and IgD.
If a person has specific gluten enteropathy, (A biopsy is the only true way of finding out) , which has stimulated an autoimmune response causing Dermatitis Herpetiformis; removing the gluten from the diet will of course help and stop the inflammation in the gut etc. and the blistering and lesions may improve in the skin a little, but it will take a long time for the autoantibody deposits to get out of the skin. Autoimmune disease cannot be cured, it is part of the genetic make-up of people who have this predisposition. Autoimmune disease occurs in children as well as adults, however in Autoimmune bullous diseases of the skin it lasts usually about 3 years, and reaches a peak, then it usually burns itself out before/at puberty.
All autoimmune disease waxes and wanes in severity, there are often periods of remission, my own period of remission was 18 years! There are unlikely to be remission periods over the age of 45, the goal is to control the autoimmune disease to such a degree that one can tolerably live with it. All autoimmunity is being researched under the same umbrella, and the way forward is to discover exactly how these normal cell processes, the antibody and target antigens malfunction, within this abnormal response. In order to remove the genetic predisposition one would need a bone marrow transplant, which of course is too life threatning , especially as the manifestation of these conditions, ( if stimulated by drugs or non-self factors such as gluten) can be resolved to some degree, although the predisposition to autoimmune disease cannot be resolved nor will ever go away. Usually, especially in idiopathic autoimmune disease involving the skin, life-long maitenance doses of immunosuppressants are necessary. Please note that ANY Autoimmune Bullous disease ( an autoimmune disease which blisters the skin) can cause blindness, as it did to me.
If anyone is interested in further info; there are excellent sites on The Immune system itself.

Last edited by cottonsocks; 09-16-2007 at 05:22 PM.

 
Old 09-17-2007, 07:29 PM   #6
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angela72 HB User
Thumbs up Re: autoimmune enteropathy?

Cottonsocks - you sure know your immune system and diseases that are problems for it.

With my daughter, she does have JRA (Juvenile Rheumatoid Arthritis - dx at age 22 months) and autoimmune enteropathy. Of course, she also has other problems in a nutshell that are "mysteries" to the doctors for many years.

One MD thinks she may have SLE (system lupus erythmatosus -sp?) - and she has many of the symptoms, but they keep backing away from that one.

I have vitiligo - so does my dad and his sister. I'm not sure of any other autoimmune problems in the family. My vitiligo is extreme, whereas I did not know my dad nor my aunt had it - very mild.

What are some good websites for the immune system?

 
Old 01-29-2008, 05:47 AM   #7
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cottonsocks HB User
Re: autoimmune enteropathy?

Quote:
Originally Posted by angela72 View Post
Cottonsocks - you sure know your immune system and diseases that are problems for it.

With my daughter, she does have JRA (Juvenile Rheumatoid Arthritis - dx at age 22 months) and autoimmune enteropathy. Of course, she also has other problems in a nutshell that are "mysteries" to the doctors for many years.

One MD thinks she may have SLE (system lupus erythmatosus -sp?) - and she has many of the symptoms, but they keep backing away from that one.

I have vitiligo - so does my dad and his sister. I'm not sure of any other autoimmune problems in the family. My vitiligo is extreme, whereas I did not know my dad nor my aunt had it - very mild.

What are some good websites for the immune system?

 
Old 01-29-2008, 07:10 AM   #8
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cottonsocks HB User
Re: autoimmune enteropathy?

Quote:
Originally Posted by angela72 View Post
Cottonsocks - you sure know your immune system and diseases that are problems for it.

With my daughter, she does have JRA (Juvenile Rheumatoid Arthritis - dx at age 22 months) and autoimmune enteropathy. Of course, she also has other problems in a nutshell that are "mysteries" to the doctors for many years.

One MD thinks she may have SLE (system lupus erythmatosus -sp?) - and she has many of the symptoms, but they keep backing away from that one.

I have vitiligo - so does my dad and his sister. I'm not sure of any other autoimmune problems in the family. My vitiligo is extreme, whereas I did not know my dad nor my aunt had it - very mild.




What are some good websites for the immune system?
Hello angela, it is a long time since I last posted, and I apologise for not getting back sooner, so I hope you read this.
I presume by saying autoimmune enteropathy you are meaning Gluten enteropathy? or Coeliacs disease?
I have explained what that is, and removal of the wheat from the diet will remove the resulting irritation from that, however, if say your child does have lupus also, which was maybe triggered by the gut allergy, it will not rid the person of lupus.
Autoimmunity simply means an abnormal immune response occurring of and to *self.* Within this abnormal immune response, abnormal antibodies are produced, called autoantibodies.
All autoimmune diseases come under the same umbrella of autoimmunity. The manifestation may be different, and the symptoms of that manifestation different, but the characteristics of autoimmunity apply to everybody who has this mutated or faulty gene.
These characteristics are...
1) The manifestation of the abnormal immune response (autoimmune response) waxes and wanes in severity throughout the period of activity
2) remission periods can be of long or short duration, but usually when young. I went into remission for 18 years! A child with autoimmune bullous skin disease, usually returns to normal at puberty. Only 12% of children carry it into adulthood.
3) DIET cannot cure autoimmune diseases- period, Not even those with gluten enteropathy, BUT if say the GE stimulated another autoimmune disease like Dermatitis Herpetiformis, then diet will control it, however the disease once stimulated takes from months to years to disappear, as long as the gluten remains removed from the diet.
4) there is no cure, unless a drug can be found to disable the mutated gene. Foods cannot repair a faulty gene, nor within an autoimmune response the resulting malfunctioning of the chemically signalling cells of the immune system. The goal of treatment is Control, enough to suppress the disease, yet have a viable immune system.
5)A person can have more than one autoimmune disease
6) Only people who have this genetic predisposition to autoimmunity can have these diseases, however they are not all hereditary, unlike psoriasis or diabetes. Hereditary disease is a genetic predisposition to a specific disease itself.
7) Autoimmune disease can be idiopathic (occurring of self, spontaneously and for no apparant reason) or stimulated by non-self factors, which the person has a definate allergy to, such as gluten, certain drugs, chemicals. These are known as enviromental factors. These may trigger the already present genetic predisposition, (and always will be) but once removed from ingestion, the autoimmune response will not occur again, but it takes time for the manifestation to disappear.
Please note that anybody with an autoimmune bullous (blistering) disease of the skin, can be in danger of that disease going into the eyes. Upon diagnosis with a bullous disease, the person must be sent to a corneal specialist, so that that door remains open for them , should they need it. These conditions are rapid in these tissues, and regular checks must be made, because symptoms often are not noticeable until the disease has already caused serious damage. I lost my sight totally due to this.
If you just ****** for "understanding immunity" there are lots of sites, some with very simple explanations of how cells of the immune system interact with one another, and with diagrams. Please remember though that when reading it is about a normal immune response to non-self factors (outside the body). To visualise an abnormal autoimmune response, think of the cell being shown of an antigen, as that being one of *self* ( of the inside of the body.)
I am not sure whether it is allowed to leave a link to a site explaining the cells of the immune system, but this one is good easy one to understand.
[url]http://nobelprize.org/educational_games/medicine/immunity/immune-detail.html[/url]

Last edited by cottonsocks; 01-31-2008 at 06:42 AM. Reason: needed to add a link if allowed?

 
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