Anybody else out there have this? I've been diagnosed for years with UCTD--my rheumy has told me he is sure it's lupus that hasn't differentiated yet. Anyway, I'm on 400mg Plaquenil daily, and colchicine 0.6mg that I started about 3 months ago for presumed Behcet's disease due to the multiple, frequent mouth sores, and genital ulcer I had a couple of months ago. I am absolutely miserable. I am really not getting any better, yet my labs never show anything conclusive. I also have anti-phospholipid syndrome. I am getting frustrated. I have noticed an improvement with the body aches/fatigue on a daily basis since starting the colchicine, but am getting very frustrated. Anyone have any ideas?