I had some blood work by my neurologist because I have periphial neuropathy. He was concerned because of reduced feeling in feet, and to a lesser case finger, as well as dry eye/mouth problem & diagnosis of gastoparesis last year, that something was working on the nerves.
The results came back & were ok except the MONOGAM SERUM INITIAL, BL. It noted: Hypogammaglobulinemia is present. Immunofixation shows no evidence of a monoclonal protein.
I don't now what the immunofixation means. My IGG & IGM was below normal. My allergist/immunologist said it could be from an infection. She wants to test again in a month with some sort of Titer test. I am not sure what that is. Meanwhile, my neurologist said we don't know the cause of the neuropathy which occurs in about 30% of cases. I had an ANA test about 6 years ago, but it was ok.
Is is there no correlation between my neuropathy & blood test? Is it possible to have a low antibody test one time & normal the next? Not sure what to make out of all this.
I had some blood work by my neurologist because I have periphial neuropathy. He was concerned because of reduced feeling in feet, and to a lesser case finger, as well as dry eye/mouth problem & diagnosis of gastoparesis last year, that something was working on the nerves.
The results came back & were ok except the MONOGAM SERUM INITIAL, BL. It noted: Hypogammaglobulinemia is present. Immunofixation shows no evidence of a monoclonal protein.
I don't now what the immunofixation means. My IGG & IGM was below normal. My allergist/immunologist said it could be from an infection. She wants to test again in a month with some sort of Titer test. I am not sure what that is. Meanwhile, my neurologist said we don't know the cause of the neuropathy which occurs in about 30% of cases. I had an ANA test about 6 years ago, but it was ok.
Is is there no correlation between my neuropathy & blood test? Is it possible to have a low antibody test one time & normal the next? Not sure what to make out of all this.
If your IgG and IgM are 2 standard deviations below normal range (whatever your labs range is), they may be looking at Common Variable Immune Deficiency or Hypogammaglobulenemia. The "titers" you mentioned are: they will give you a pneumonia and tetanus vaccine, then wait 3 weeks, draw your blood and see if you mounted a response (made antibodies - titers would be your levels). If no to at least one of those, then you may have cvid which is uncureable but a very treatable Primary Immune Deficiency Disease. It presents differently in people: most have gut issues like IBS, some, like me, were constantly sick (like 20 infections per year). Autoimmune disease is very common in people with CVID.
Thx for insight. I am similar in I suffer frequent sinus infections. Actually on an antibiotic & medpac now (dosed prednisone). If I did my math correctly, I exceed the 2 std deviations. Will take another blood test in 3 weeks. Best wishes on your treatment and good health.
Had follow up bloodwork. Igg & Igm lower than last month test. CBC is normal. Dr waiting for additional blood test results, including igg subclass for interPretation. I assume I will receive cvid diagnosis but not sure. Any thoughts?
CVID is only diagnosed once you are immunized and then titers are drawn 3 weeks later. If low or no response in combination with your low IgG and IgM, you get a diagnosis
The Following User Says Thank You to cvidmama For This Useful Post: mws952002 (03-27-2012)
[QUOTE=mws952002;4935133]I had some blood work by my neurologist because I have periphial neuropathy. He was concerned because of reduced feeling in feet, and to a lesser case finger, as well as dry eye/mouth problem & diagnosis of gastoparesis last year, that something was working on the nerves.
I also have hypogammaglobulinemia along with a lot of other autoimmune issues. They are now suspecting that I have Sjogrens Syndrome-the biggest symptom is dry eye/dry mouth and I also have tingling in my hands and feet and gastroparesis-all symptoms of this syndrome.
We thought these symptoms were due to all of my other medical problems until we found a positive SSB (La) test in my records from a visit to Cleveland Clinic many years ago. Since then, however, I have had negative tests, so it can be tricky to diagnose.
Had follow up blood work. Igg & Igm lower than last month test. CBC is normal. Dr waiting for additional blood test results, including igg subclass for interPretation. I assume I will receive cvid diagnosis but not sure. Any thoughts?
I have Hypogammaglobulinemia as well, was told back in 2009 about it.. my Oncologist thinks it is jut from all the chemo and transplant and such with me, but my immunologist based on my past medical history and symptoms as well as current believes I have always had an immune disorder that went undiagnosed due to the dr I had as a child.
The Following User Says Thank You to Nhlsurvivor2008 For This Useful Post: mws952002 (11-13-2012)
so after you are vaccinated they will draw your blood in 3 weeks to see if you mount a response.
