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Old 04-22-2013, 03:20 PM   #1
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puffygirl74 HB User
High IgM, low IgG (subclass 4) elevated WBC

I am a 38 y/o female with a history of allergies, sinus infections and UTI's. I have seen 7 different specialists over a 5 year time period for the following symptoms:
1. joint pain and swelling (hands, feet, knees, hip)
2. facial swelling (puffy eyes and cheeks)
3. recently a non-itchy red rash on ear lobe spreading across neck and face
4. abdominal distention (makes me look bigger than I was when I was 9 months pregnant)
5. bouts of diarrhea with bad cramping
6. pain under the left rib cage that radiates to my back (flank) and my left shoulder
7. fatigue (sometimes so bad I can't stand)
8. bad metal taste in mouth (intermittent)
9. urinary urgency
10. gagging sensation
11. sometimes I feel so much pressure in my head I think it might explode but it's not from sinus pressure
12. tachycardia
13. low bp


I recently started seeing an allergist/immunologist who ordered a complement panel and some immunity tests. The following was elevated:

IgM
WBC

IgG subclass 4 was low

So I'm waiting on my follow up with my new doc about these test results and I am just so frightened that I will get the quizzical look as if he has no idea what to do for me but understands there is something wrong. Any ideas of questions I should ask or what might be causing or contributing to my symptoms? Any assistance would be greatly appreciated as I just don't have much fight left in me.

M

 
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Old 04-22-2013, 06:10 PM   #2
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Re: High IgM, low IgG (subclass 4) elevated WBC

Have you been tested for autoimmune disease, like lupus? It can cause many of the symptoms and lab abnormalities. Do you know how high your WBC was? I would see a rheumatologist if autoimmune disorders haven't been considered or tested.

 
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Old 04-23-2013, 07:52 AM   #3
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puffygirl74 HB User
Re: High IgM, low IgG (subclass 4) elevated WBC

Thank you ladybug. I was tested for Lupus a few years ago and it was negative. Do you know if that is something that I should have re-tested every so often?

My A/I doctor called yesterday and said he is thinking Hereditary Angioedema Type 3 along with some other immune system issues.

 
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Old 06-29-2013, 07:08 PM   #4
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ourday17 HB User
Re: High IgM, low IgG (subclass 4) elevated WBC

I have IGG subclass deficiency and received IVIG infusions. I experienced the same symptoms as you. I see both my Asthma and Rheumatoid doctors. I have been on the infusions for 9 months and I am feeling so much better than in the past.

 
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Old 06-29-2013, 08:18 PM   #5
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Re: High IgM, low IgG (subclass 4) elevated WBC

I think people who have autoimmune symptoms should get tested every 6-12 months, particularly during a flare or if new symptoms crop up. Negative tests can turn positive over time, so once is not enough. Many of your symptoms sound autoimmune.

 
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Old 07-04-2013, 12:20 PM   #6
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diamondgirl55 HB User
Re: High IgM, low IgG (subclass 4) elevated WBC

Quote:
Originally Posted by puffygirl74 View Post
I am a 38 y/o female with a history of allergies, sinus infections and UTI's. I have seen 7 different specialists over a 5 year time period for the following symptoms:
1. joint pain and swelling (hands, feet, knees, hip)
2. facial swelling (puffy eyes and cheeks)
3. recently a non-itchy red rash on ear lobe spreading across neck and face
4. abdominal distention (makes me look bigger than I was when I was 9 months pregnant)
5. bouts of diarrhea with bad cramping
6. pain under the left rib cage that radiates to my back (flank) and my left shoulder
7. fatigue (sometimes so bad I can't stand)
8. bad metal taste in mouth (intermittent)
9. urinary urgency
10. gagging sensation
11. sometimes I feel so much pressure in my head I think it might explode but it's not from sinus pressure
12. tachycardia
13. low bp


I recently started seeing an allergist/immunologist who ordered a complement panel and some immunity tests. The following was elevated:

IgM
WBC

IgG subclass 4 was low

So I'm waiting on my follow up with my new doc about these test results and I am just so frightened that I will get the quizzical look as if he has no idea what to do for me but understands there is something wrong. Any ideas of questions I should ask or what might be causing or contributing to my symptoms? Any assistance would be greatly appreciated as I just don't have much fight left in me.

M

 
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Old 07-04-2013, 12:31 PM   #7
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diamondgirl55 HB User
Re: High IgM, low IgG (subclass 4) elevated WBC

Have you seen an immunologist?
It might be a good idea to determine if you have a primary immune deficiency. Sinus infections, joint inflammation, and gastrointestinal issues are all part of this diagnosis.
It might be an idea to ask, as most physicians dont think to test for it, even if IGG levels are low.
If you check out the Immune Deficiency Foundation website, there is a lot of information on this disease and how it is diagnosed and treated.
There are a number of publications that you can ******** as pdf files,and take to your doctor. That way your doctor might be learning something, and can help you at the same time.

 
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