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Old 11-26-2004, 02:57 AM   #1
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elevated enzymes; AMA ???

I've had elevated enzymes (ALT, AST) for awhile now, and my doctor thought it was time for me to see a liver specialist. My AST on the last test was 58; ALT was 129; AMA 1:80. ALK Phos. was in the normal range at 110.
I have high cholesterol and osteopenia, and I'm in my late 40's.

Does this sound like PBC?

 
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Old 11-28-2004, 01:45 PM   #2
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Re: elevated enzymes; AMA ???

Quote:
Originally Posted by Wendy379
I've had elevated enzymes (ALT, AST) for awhile now, and my doctor thought it was time for me to see a liver specialist. My AST on the last test was 58; ALT was 129; AMA 1:80. ALK Phos. was in the normal range at 110.
I have high cholesterol and osteopenia, and I'm in my late 40's.

Does this sound like PBC?
I forget if you were the one who posted on another forum about something like this. Anyway, the answer to your question is that this COULD be PBC. Being a woman, you are at much higher risk for developing PBC than a male your age would be. Your ALT is slightly raised, and the fact that your AMA is positive does point towards the disease; however, it's still hard to say.

Have you had any of the symptoms of PBC? For those of you reading this thread, PBC stands for Primary Biliary Cirrhosis which is a disease of scarring of the bile ducts in the liver.

 
Old 11-28-2004, 06:57 PM   #3
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Re: elevated enzymes; AMA ???

Quote:
Originally Posted by butterflytrans
I forget if you were the one who posted on another forum about something like this. Anyway, the answer to your question is that this COULD be PBC. Being a woman, you are at much higher risk for developing PBC than a male your age would be. Your ALT is slightly raised, and the fact that your AMA is positive does point towards the disease; however, it's still hard to say.

Have you had any of the symptoms of PBC? For those of you reading this thread, PBC stands for Primary Biliary Cirrhosis which is a disease of scarring of the bile ducts in the liver.
Thanks butterflytrans for your response

No, I didn't post on another forum. There is another post on this forum by someone with a similar situation, but that person did not have an elevated AMA.

As far as symptoms....I have high cholesterol, almost @ 300. I've ALWAYS had a tendancy towards it. In my early 30's, 120 lbs, ate very healthy, non-smoker, I still had a cholesterol reading of 198.

I also have thinning of the bones. I didn't expect to get that at such an early age.

For the last couple years I've had itching on my abdomen. I figured it was from dry skin. It's not constant, as sometimes months go by and it doesn't bother me. Looking back though, it does seem like that started about the same time my ALT/AST started to be elevated.

So, is the doctor just going to wait until my ALK phos. goes up to give me the dreaded diagnosis? Is there a chance that the rise in the AMA was just a fluke, and it will be fine on the next blood test? (the doctor did say that a reading of 1:80 for the AMA was not real high) This waiting game is very hard.

 
Old 11-28-2004, 07:56 PM   #4
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Re: elevated enzymes; AMA ???

Your doctor has a point...a titre of 1:80 for AMA isn't that high, but the thing is, it really shouldn't be positive to begin with. The itching on your abdomen obviously goes with PBC, and the fact that you're a woman (I think you are at least! *heehee*) goes towards the diagnosis as well. In terms of your cholesterol, sorry, it's hard for me to help you because the units are not the same ones we use here in Canada.

Have you e'er been jaundiced before?

 
Old 11-28-2004, 08:38 PM   #5
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Re: elevated enzymes; AMA ???

Yes, I am a woman! (heehee) No, I have never had jaundice. Bilirubin total is 0.3 (0.2-1.3), and the bilirubin direct is 0.1 (0-0.4).

What are other reasons a person may have an elevated AMA, other than PBC? If it was PBC, wouldn't my ALK Phos. already be elevated?

 
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