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Old 11-13-2003, 12:33 PM   #1
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Question Help W/blood Test Results

Anti Nuclear Ab- Positive
Ana Titer - 1:32
Ana Pattern- Homogeneous
Speckled
Anti Scl 70 Ab-eia Abnormal
Scl 70 Weak Positive (30)
Scl 70 Ab, Immunodifusion Normal
Scl 70 Westblot Positive (abnormal)
Anti Ro Ab Ss-a Eia Moderate Pos Diagnosis Sjogrens Syndrome
Anti La Ab Ss-b Eia Weak Positive (21)


Any Idea What The Other Stuff Means?

 
Old 11-13-2003, 01:06 PM   #2
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Yikes!

Your mom really is flaring BIG time. Did you mean 1:320 instead of 1:32? I think it may have been a type-o. I can tell you what this all means.

Anti Nuclear Ab- Positive <--- Means her ANA is positive
Ana Titer - 1:32 <--- I think you meant 1:320? That is very positive
Ana Pattern- Homogeneous
Speckled <--- Indicates LUPUS pattern, this pattern is indicative of Lupus
Anti Scl 70 Ab-eia Abnormal <--- See below
Scl 70 Weak Positive (30) <--- See below
Scl 70 Ab, Immunodifusion Normal
Scl 70 Westblot Positive (abnormal) <--- see below
Anti Ro Ab Ss-a Eia Moderate Pos Diagnosis Sjogrens Syndrome
Anti La Ab Ss-b Eia Weak Positive (21) <--- see below

The Scl 70 test indicates that your mom may have Scleroderma. Do you know what Scleroderma is? It is what COULD be responsible for your mom's skin problems! It is a disease in which the symptoms may either be visible, as when the skin is affected, or invisible, as when only internal organs are involved.
It is also a highly-individualized disease. Its involvement may range from mild symptoms to life-threatening. The symptoms are:

Raynaud's Phenomenon (abnormal sensitivity to cold in the extremities).
Swelling of the hands and feet
Pain and stiffness of the joints
Thickening of the skin
Joint contractures
Digestive system and gastrointestinal tract problems
Sjogren's Syndrome (dry mucus membranes) (Your mom is positive for this too!)
Oral, facial and dental problems
Kidney, heart, and lung involvement
Non-specific symptoms such as extreme fatigue, generalized weakness, weight loss, and vague aching of muscles, joints and bones

Since she was slightly positive for the Anti-Scl 70 then perhaps its mostly dormant for now?

It sounds like your mom has plenty more than just Lupus going on here. Has she been officially diagnosed with Sjogren's Syndrome or Scleroderma? Those can be treated along with the Lupus. It's all called "Overlap Syndrome" the way they intertwine into each other.

The Anti-La just indicates that Lupus is occuring as well. ALl of these tests being so abnormal means that your mom is in quite a flare Deb. She needs a GOOD Rheumatologist to sort her out. No wonder she is so grumpy! I hope that you guys can get into the new Rheumy SOON. What was your mom's ESR at?

Luv and hugs!!

~Dana

 
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Old 11-13-2003, 01:27 PM   #3
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Hi
Yes her ana was 1:320
Well her current rheumy did diagnose her with Sjogren's
syndrome, but he didn't mention anything about the SCL-70
westblot being positive, and the anti scl-70ab-eia being abnormal
nor the scl-70 being a weak positive. But like yourself I am concerned
that she might have this skin disorder, but you know how Dr. Doolittle
is so He may have passed this up!!!!!!!
I didn't see the ESR on her test results so I guess he passed this up
(maybe he was afraid of not being paid for that test)
As far as the concern about Schleraderma (sorry spelling)
I gave her dermatologist a call so maybe she can read it
more carefully. I didn't have faith in the rheumy enough
to call him up
I will keep you informed of what the dermatlogist says
Luv
Pinky

 
Old 11-13-2003, 01:50 PM   #4
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Hi,
Just heard from her dermatologist, she says that she has a lot
of immunological abnormalties in her blood and that she may or may
not have schleraderma (spelling sorry) She says that eventhough a test is
positive for the disease it doesn't mean that she is symptomatic at this time.
And recommended the rheumy that we are going to see in January.

Still puzzled?????
Pinky

 
Old 11-14-2003, 10:18 PM   #5
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Hey Deb,

I am glad that the Dermatologist did get back to you. That is VERY puzzling for a response from the Dermy that's for sure! Her blood work indicates that Scleroderma is going on, so I don't know why she said she is asymptomatic?? That is odd. Does your mom have lots of different looking rashes? Like more than that one grannule rash. Take care Deb!!

~Luv, Dana

 
Old 11-17-2003, 06:31 AM   #6
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Question Still Puzzled

Yes, I thought the same thing because 2 out of the three scl-70
tests were abnormal, but maybe because she has a flare up this might
be making everything come out abnormal?

 
Old 11-17-2003, 06:46 AM   #7
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also, maybe because the scl-70 ab, immunodiffusion
was NORMAL,? its considered not to be the disease?

 
Old 11-17-2003, 07:05 AM   #8
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More info:

I just got off the phone with her current rheumy and
he says not to worry because ONE out the the four
SCL-70 tests is NORMAL ??
Im skeptical but I guess you have to have all of the abnormal
??

 
Old 11-17-2003, 08:17 AM   #9
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Well I disagree with his decision that only ONE is positive. From the information that you gave me here, I see that 3 are positive! I am glad that your appt with the new Rheumy isn't too far off, I would try and stay away from this one... he doesn't sound that bright! January isn't too far.. I will count down the days and pray that your mom is feeling alright until then! Is your GP good? I hope so. Sheesh! Take care Deb, luv and Hugs!

~Luv, Dana

 
Old 11-17-2003, 08:22 AM   #10
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Hi

Well I feel the same way you do actually the Immunodiffusion
method was normal, but the other methods , like the Westblot
was positive? Im confused about this one.???????
We need a good rheumy to evaluate this ....this is a
tough question to be answered.

 
Old 11-17-2003, 08:24 AM   #11
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ALL of those tests with the Scl in front of them are related to the same thing. I think that your current Rheumy is a bone head! Hahahaha! Just take it as easy as you can. How is your mom doing with her moods? I hope that things are getting better. Talk to you soon! It's sorta cool that we are online at the same time! I have to go tidy up this house though.. dust bunnies are taking over. take care!!!

~Luv, Dana

 
Old 11-17-2003, 08:26 AM   #12
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we can't get in to see this new rheumy 'til January but
his associate is avail in dec., we just might go to see him
in the meanwhile.
The other Dr. Doolittle, just sent her off with these blood
results and doesn't want to see her 'til January.

Now she is complaining if hot burning sensations in her
throat and pelvic area.
I think we should see this other associate. I don't believe
what Dr. Doolittle says.

 
Old 11-17-2003, 08:35 AM   #13
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Don't work too hard around the house....
Later
Pinky

 
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