I have Lupus and Rheumatoid Arthritis. I have been taking Plaquenil for one year along with steroids. I am weaning off the steroids right now due to Cushings effects. I started Enbrel for the RA one month ago. My rheumy left the country and I saw his partner last week. He is concerned that the Enbrel can actually produce an antibody and make the Lupus worse. I have already tried Methotrexate injections and Arava pills. So, he wants to start Remicade IV or Imuran - I have to decide by January on which one I want. He said that the Imuran will treat the dual diagnosis. I understand that it is in a pill form. I have had some serious stomach issues from all the NSAIDS and other meds, does Imuran have a reputation for stomach upset? Anything that you guys can share about these drugs would be great. Personal experiences work better for me than what the books say!