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Old 03-20-2006, 06:11 AM   #1
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difference between anti-ro and ana?

I hear a lot of people talk about ANA being negative and anti-ro being positive-- i think in people with SCLE? does anyone know which blood antibody test they use for sjogrens? I thought it was anti-ro? because as for lupus, i am sure they only tested me for ana, but they did do sjogrens and if they was anti-ro well then i suppose i am in the clear for lupus and its back to wondering... i have a followup with rheum. on monday, what should i ask her regarding the tests she did--whhat tests should be done to rule out all lupus?
hope everyone is well..
michelle

 
Old 03-20-2006, 08:56 AM   #2
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Re: difference between anti-ro and ana?

Hi, Michelle. The following is only how I understand these things. I'm just a patient, though, so this is only for what it's worth...

Anti-Ro is seen in BOTH SCLE-type lupus AND Sjogren's. (But I also think you maybe can be Dx'ed with *SLE* with this antibody, if you meet the most severe of the SLE criteria.)

It's really the totality of your symptoms & other test results that indicate to a rheumie which, Sjogren's or lupus, you have. Or you can have BOTH.

ANA is only a "threshhold" test that can be positive in various autoimmunes, due to a family tendency, due to a pssing virus, etc. In & of itself, it doesn't say a tremendous lot, though I bet if it were "horribly" high, that would inspire a dr. to really search very hard for answers.

As for ANA in SCLE: I was told it's *positive* about 2/3 or so of the time, meaning it's negative about 1/3 of the time. So having a negative ANA & a positive anti-Ro may *doesn't* mean you are in the clear for lupus.

But I also had SCLE-type rashes, so skin biopsy results were a big part of the Dx for me.

For Sjogren's, there are additional specific tests such as dry Schirmers & Rose Bengal corneal. But the most accurate, I think I read, is lip biopsy.

My suburban drs. (multiple rheumies & dermies) had never seen SCLE, I suspect---vs. my city drs., who sized me up in, oh, about 2 minutes each. So it would be really good for you, if your anti-Ro is positive, if you knew that your rheumie had seen/treated both SCLE & Sjogren's, alone or together.

There is no one test that rules out all lupus, is my understanding. I think this is where symptoms over time add/subtract to the diagnostic process, and additional testing as warranted, also.

I wonder if Sjogren's is treated with the same meds as non-organ-threatening lupus, whether Plaquenil is the DOC for both? That maybe would be a question to ask.

I really hope this makes sense. Please give a yell if it doesn't, OK? Otherwise, good luck with your upcoming rheumie appt! Sincerely, Vee

 
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Old 03-20-2006, 09:51 AM   #3
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Re: difference between anti-ro and ana?

Hey, guys!

Don't know if this helps, but I am positive for both ANA and anti-ro and have a dx of SLE. My first symptom, though was in 1989 (severe autoimmune thrombocytopenia) and at that point all my tests were "fine" except obviously my platelet count, and my SED rate and anti-platelet antibody titer. It wasn't until May of 2005 that my ANA flipped to positive (and I have had it run many times since 1989 'cause I've felt like junk for a lot of those years). So, so much for the theory that ANAs don't change!

Hope you get some answers soon.

Take care and God bless!
Michelle in CA

 
Old 03-20-2006, 10:42 AM   #4
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Re: difference between anti-ro and ana?

Burnt Bees, Michelle just wrote that her ANA took awhile to turn positive. A woman I know had a similar progression of test results going positive, with an extra twist: first anti-Ro; several years later anticardiolipin; then awhile after that the ANA.

Kinda like the rule is that there IS no rule...? Vee

 
Old 03-20-2006, 04:16 PM   #5
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Re: difference between anti-ro and ana?

thanks everyone---but i don't have any skin rashes and my first symptom was blurred vision, but no optic-neuritis, i still think it could be ms, even though my MRIs were clear... i just don't anymore!!

 
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