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Old 04-06-2006, 10:26 AM   #1
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Burnt Bees HB User
what does a negative ANA test actually mean?

Hello.

I tested negative for ANA, but havent't gotten any other tests done, as i know there are many other antibodies to be checked for (anti-ro, anti-sm, etc.) Does a negative ANA rule out SLE, as I know people test negative for ANA but still have the subset SCLE. I am confused. If anyone could clear this up, I would greatly appreciate it.

Thanks,
Michelle

 
Old 04-12-2006, 05:58 AM   #2
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Re: what does a negative ANA test actually mean?

Burnt Bees, Here's what I've read & have been told. In all cases, figures vary from source to source & maybe even change as more understanding is gained about all the varying forms of the disease.

In SLE, ANA is "almost always" positive (over 95%, maybe over 97%---figures vary).

In the SCLE subset, ANA is positive perhaps only 2/3 of the time or so.

In the DLE subset, ANA is positive perhaps only 50% of the time or so.

(Not sure about the odds neo-natal & drug-induced lupus. Sorry.)

BUT---even with the rough "facts" above, it can take multiple tests before a positive result is found, due to flares, due to someone seeing a dr. very early on in the disease process, due to differences in lab procedures, etc.

Vee

 
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