I'm on 15 mgs of prednisone a day and methotrexate once a week, 8 little pills. I have swollen knees and ankles as well and feel achy all over in general. I am ana positive and have a general connective tissue thing going on. After all the meds, I still don't feel very well . I finally decided to dish out the $ 275.00 and go to a holistic dr. He is also well practiced in the "medical field." New to me, but dr's aren't trained to get to the root of diseases and fix them. They prescribe meds peroid. My holistic dr. tells me that most diseases are due to "food allergy" very complex but it makes sense. And mercury poisoining is another thing people should be tested for as well. My rhumy dr. mentioned something about the cause to be " hormonal " ok, when i asked this holistic dr, he said it MIGHT BE and lets test you for estrogin and progesterone inballances and fix them !! There is a source to every health issue. And what you eat consists of 50% of your general health. Anyway... i have decided to go on this " elimination diet " and take out all grains, dairy, sugar, most meats, preservitives, citrus and i forget whatelse. I try it for one month and if feeling well , try reintroducing each food back into my diet to see if i react to it, and see if there is a food allergy. Who knows !! W/b if you have any ?? I am so facinated by all this i just had to share !!!!