Re: they are thinking lupus again
Erfan, I found out the hard way that there are "subsets" of lupus in which ANA can be negative. I have SCLE = subacute cutaneous LE, in which 30% or so are ANA-negative. I think in the past this was called "Ro-lupus", but in the late 1970's, it was given its own descriptive name. But I'd say the name is misleading, as it can go full-blown systemic. 50% of those with SCLE score 4 or more on the "4 of 11" SLE criteria, although the group tends to have less kidney & CNS involvement, or so it's thought...
And in DLE (discoid lupus), 1/2 are ANA-negative. About 10% of people who have discoid (scarring) lesions go on to systemic lupus.
It took my going to a teaching hospital rheumie to get answers. I also had one final skin biopsy done by a dermatopathologist. There are two SCLE-specific rashes: annular (targetlike) & psoriasiform (resembles psoriasis, to the naked eye, but isn't). I had the annular (circular) form. Like most people with SCLE, the antibody that finally showed as positive was anti-Ro.
Bottom line? Being ANA-negative is not proof you don't have lupus, unless, of course, the doctors telling you this REALLY REALLY understand the "subsets". Best wishes, Vee
Last edited by VeeJ; 11-10-2007 at 04:01 AM.