It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....



Lupus Message Board
Post New Thread   Closed Thread
LinkBack Thread Tools
Old 11-24-2007, 09:39 PM   #1
Senior Member
(female)
 
Join Date: May 2004
Posts: 107
marcie23 HB User
ANA Test Positive

I recently had my yearly physical. I'm concerned about the test results.
Does this mean Lupus? I have no symptoms or family history.

ANTI-NUCLEAR AB POSITIVE
ANA W/Titre & Pattern Homogeneous 1:160 H
RHEUMATOID FACTOR NEGATIVE

 
Sponsors Lightbulb
   
Old 11-25-2007, 05:25 PM   #2
Facilitator
(female)
 
Join Date: Feb 2004
Posts: 5,058
VeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB User
Re: ANA Test Positive

Hello. A positive ANA does not by itself diagnose systemic lupus (SLE). The diagnosis is instead a combination of clinical & test results. The full criteria are listed on a "sticky post" (permanent info post) at the top of the thread list. To be Dx'ed with SLE, you must meet at least 4 of the 11, at some time in your life, meaning not necessarily simultaneously. Think of each being checked off in indelible ink once it's met.

ANA can be positive in SEVERAL conditions, not just in lupus, e.g., rheumatoid arthritis, myositis, scleroderma, Sjogren's syndrome, etc. Also, it can be positive due to simply a passing virus, or even to a family tendency.

You'll see that only two specific autoantibodies are included: anti-ds-DNA & anti-Sm. There are actually many more POSSIBLE in lupus, but only these two are considered totally unique to lupus, while the others can be seen in multiple conditions. Were the specific tests run for these autoantibodies, too? e.g., for anti-Ro, anti-La, anti-RNP, etc?

A final thought: the criteria apply only to full-blown "classic" lupus = SLE. But there are OTHER kinds (subsets), too, for which you don't have to meet 4criteria. The mildest is discoid lupus (DLE), characterized by scarring skin rashes; you generally meet only a few criteria. The intermediate kind is called subacute cutaneous (SCLE); and in it, you may meet less than 4 or more than 4. While SCLE problems can range across the full SLE spectrum, the odds for the worst problems seen in SLE (CNS & kidney) are believed to be lower in SCLE than in SLE.

This looks like a good place to stop so you can read. I hope you post again soon, when you can. Bye for now. Best wishes, Vee

 
Sponsors Lightbulb
   
Old 11-30-2007, 01:41 AM   #3
Newbie
(female)
 
Join Date: Nov 2007
Location: New Brunswick
Posts: 1
jackyeli HB User
Exclamation Re: ANA Test Positive

Hi,

I recently had a blood test done and the ANA can out positive-very high...but im 19 and so im really young...i have no other signs of lupus-nothing hurts, etc. I dont know if I have lupus but i want to know can the number of ANAs in your body ever reduce????

Does stress and something else cause them to get higher??? Please help!!! thanks!!!!

 
Old 11-30-2007, 06:48 AM   #4
Facilitator
(female)
 
Join Date: Feb 2004
Posts: 5,058
VeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB UserVeeJ HB User
Re: ANA Test Positive

Jackyeli, Hello & welcome. I'm only a patient (obviously!) & this is only intended to encourage you to ask more questions of your dr. In your shoes, with a very high ANA, I'd ---

1. Ask your dr. if specific autoantibody tests were done, for example, anti-ds-DNA, anti-Sm, anti-Ro, anti-La, Rheumatoid Factor, etc. Hopefully these tests were already done, IN ADDITION TO the ANA test. Why? Because ANA is only a threshhold test, and just by itself, it can't diagnose anything.

Did your dr. say anything at all about high ANA values? I know I've read that it can elevate just due to a passing virus, but I'm not sure high a virus might cause it to go.

I've also read that it can go VERY high, particularly in Sjogren's syndrome &/or in lupus. But I don't know how high it can go in OTHER conditions that typically feature a positive ANA (like RA, scleroderma, myositis, etc.)

Are you taking any meds that can trigger a positive ANA in some people? There's something called drug-induced lupus (DILE), which, unlike classic lupus, tends to resolve when the offending drug is discontinued.

I've also read that lab errors can make ANA appear higher than it really is. In a titer-style test, a boo-boo can actually double the result. In short, labs & procedures vary a lot, so titer-test results are viewed as a little "squishy".

2. Did your dr. order urinalysis? If not, you could ask to have it done, to check for protein in your urine.

I hope you talk more to your dr. & also that others here chip in soon, too. Meanwhile, sending you my best wishes. Vee

 
Old 11-30-2007, 09:50 AM   #5
Senior Member
(female)
 
Join Date: May 2004
Posts: 107
marcie23 HB User
Re: ANA Test Positive

Thanks for the replies.

I had a consult with my dr. Since my previous ANA test (in April) was negative. We will recheck in 3 mos.

Jackyeli, if you results were very high but have no symptoms, maybe you should retest? Or get further tests as VeeJ recommends. Good Luck.

 
Closed Thread

Similar Threads
Thread Thread Starter Board Replies Last Post
TB Test OBD Infectious Diseases 3 09-13-2008 08:47 AM
Test positive for herpes and then negative for type 1 and 2? Yquestion Herpes 22 10-31-2007 07:45 AM
Saw Doctor-Blood Test maree4848 Lyme Disease 23 08-06-2007 10:55 AM
HIV test is negative now - chances of positive in 3 months? nec1973 HIV Prevention 5 05-31-2007 08:40 PM
Verified Exposure to HIV (waiting to test) 81ITFIN HIV Prevention 34 11-02-2006 09:07 AM




Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off




Sign Up Today!

Ask our community of thousands of members your health questions, and learn from others experiences. Join the conversation!

I want my free account

All times are GMT -7. The time now is 07:53 AM.



Site owned and operated by HealthBoards.comô
Terms of Use © 1998-2014 HealthBoards.comô All rights reserved.
Do not copy or redistribute in any form!