Re: what is a high positive ANA'
Cpp, hi & welcome. First, there are limitations on the meaning of ANA. It's positive in multiple connective tissue diseases (Sjogren's, lupus, rheumatoid arthritis, polymyositis, ETC.) Also in some endocrine-based conditions (Hashimoto's thyroiditis, ETC.). In other things like blood disorders, ETC. And even where there's NO chronic disease: aging, a passing virus, a family tendency, ETC.
ANA has testing limitations, too. It's a titer test involving progressive dilutions of a sample, so it's difficult to perform with total accuracy. Different labs can get varying results from the same sample. (FYI, 1:1280 is just one dilution beyond 1:640.)
In his lupus hardcover, Dr. Daniel Wallace writes that he uses 1:1280 as a personal threshold---but in the context of symptoms, other tests & findings, lifetime medical history, etc. (But for all I know, other drs. could use a different level!) But main point is, ANA in & of itself doesn't provide answers.
Have you had blood tests done for *more specific* autoantibodies & complement levels? e.g., anti-ds-DNA, anti-Sm, anti-Ro, anti-La, anti-RNP, antiphospholipid, anticardiolipin, rheumatoid factor, C3 & C4 complements, ETC.? (And that's only a partial list; Dr. Wallace lists at least 16 on his BASIC list alone.)
Have you read the 3 "sticky posts" at the top of the thread list? For comprehensive writing, try your local library. Look for Dr. Wallace's lupus hardcover &/or Dr. Robert Lahita's hardcover. Both are excellent. Obviously I'm merely a patient, but I hope this helps another patient some. Best wishes, Vee
Last edited by VeeJ; 03-23-2009 at 06:40 PM.
Reason: spelling & P.S.