Hello. I have three girls, ages 16, 12, and 11. I don't really know what's going on with all of them, but I can't tell you what I know. I have connective tissue and am taking mobic and plaquenil. My 16 year old, has lupus- with brain involvement. My 11 year old tested neg for ana, but has has protein and blood in her urine for 6 months and has been getting severely anemic since. My 12 year old tested positive ana LoW, but is now seeing a nuerologist for severe muscle spasm (on valium). So if you want to talk about the possiblities. Anything is possible. I wish I could help more, but I just don't know much. Take care of yourself.