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Old 04-23-2009, 11:14 AM   #1
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Lupus tests

If the tests for anti-DNA and Sm are always negative, does that mean the lupus isn't the damaging kind where it's already damaging the organs?

Would it be the lesser kind where there's really no damage?

CindyLou

 
Old 04-23-2009, 11:42 AM   #2
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Re: Lupus tests

Hi CindyLou,
As far as my understanding goes, an anti-SM that reads positive is related to more severe cases of lupus and an anti-DNA that reads positive often suggests that the person is at a higher risk for developing lupus related kidney disease. Your best bet would be to clarify this information with your doctor because I'm just a patient lol. I hope this helped
-Erica

 
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Old 04-23-2009, 12:21 PM   #3
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Re: Lupus tests

I had asked my rheumy about those tests. I said now if the tests always show negative, then that means a person wouldn't have lupus?

He said that if it showed positive then that's the more damaging lupus rather than the less severe kind.

So then, the big question? How exactly does a doc know you have lupus if those tests are negative?

CindyLou

 
Old 04-23-2009, 12:50 PM   #4
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Re: Lupus tests

Hi CindyLou,
I completely agree with your doctor. The way a doctor would know if you have lupus and your tests are negative would be through the American College of Rheumatology's issued list of the eleven criteria needed to diagnose lupus. In order to receive a lupus diagnosis one must meet at least four of those eleven criteria.
-Erica

 
Old 04-23-2009, 02:12 PM   #5
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Re: Lupus tests

Hi Erica:

I have just 4 out of the 11 criteria for lupus.

I have rash on my face.
I have low white count.
I have neutropenia and leukopenia.
I have fevers.
I have sun sensitivity
I have heat sensitivity--the heat bothers me.

CindyLou

 
Old 04-23-2009, 02:18 PM   #6
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Re: Lupus tests

Hi CindyLou,
Has any of the bloodwork you have had indicated lupus?
-Erica

 
Old 04-23-2009, 02:21 PM   #7
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Re: Lupus tests

What bloodwork would indicate lupus? Then I can tell you if I've had them.

CindyLou

 
Old 04-23-2009, 02:27 PM   #8
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Re: Lupus tests

Hi CindyLou,
Have you had any positive results for any of the antibody tests such as anti-RO, anti-LA, anti-RNP, low levels of complement, etc.
-Erica

 
Old 04-23-2009, 02:36 PM   #9
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Re: Lupus tests

Hi Erica:

My complement levels are low. I don't know how low you mean? Mine are 0.04. Is that low? That's one of the labs I just had done.

The anti-RNP is a low number and it is 9.

Does this mean anything? But the RO I think comes out negative. I have no idea on LA--I don't think so. Doesn't sound familiar.

CindyLou

 
Old 04-23-2009, 03:01 PM   #10
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Re: Lupus tests

Hi CindyLou,
I'm not sure what unit the 0.04 result is in. Usually they're in mg/dl. Is that the unit used on the results of your C3 and C4 complement? The anti-RNP I believe is considered negative if it is less than 25, but I'm not positive-I'm sure Vee would know
-Erica

 
Old 04-23-2009, 03:51 PM   #11
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Re: Lupus tests

I goofed on what I told you about complement. That was the C-Reactive Protein. Range is on this lab 0.00 starts at low and high is 0.30. Mine is 0.04.

The C3 and C4 is this. This was from last year at this time right now. Range for C3 is 88-193 and I was 92.

C4 range is 12.00-36.00 and mine was 17.50.

So what does this look like? I don't understand any of it.

CindyLou

 
Old 04-23-2009, 03:54 PM   #12
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Re: Lupus tests

Erica:

Also last year at this time the sed rate was 12. But my ANA was 640. It always stays at 320 and that's where it is now. But in April last year the pattern was still speckled and homogenous. Just in November it switched to Nucleolar and now is Nucleolar.

CindyLou

 
Old 04-23-2009, 05:57 PM   #13
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Re: Lupus tests

Hi CindyLou,
Your complement is normal, as your test results tell you. The complement would be low if your body was having a severe immune reaction due to lupus or another cause(others things can cause this to happen but I'm not educated as to what). These results when low usually indicate an immune response primarily in the kidneys. Also the c-reactive protein is a test which measures the concentration in blood serum of a special type of protein produced in the liver that is present during episodes of inflammation or infection. The lower the number, the less inflammation.
-Erica

 
Old 04-23-2009, 06:59 PM   #14
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Re: Lupus tests

So I guess all those labwork is fine and wouldn't show anything with lupus?

Cindy

 
Old 04-23-2009, 07:09 PM   #15
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Re: Lupus tests

Hi CindyLou,
As far as what you've told me about your labwork nothing seems to be out of the norm except for your neutropenia, leukopenia and sed rate. It seems to me that your lupus is very mild which is great!

 
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