I just joined this message board, but was diagnosed with Lupus in 1997. I'm so glad to hear that Plaq. has helped you. I tried it and nothing, I mean nothing, helped with the fatigue. My only symptoms still are joint swelling and extreme fatigue. I don't usually have a lot of pain with my swelling, but I also have a high pain tollerance. But I have not tollerance to fatigue. Hope you are still feeling fine.